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Iranian Journal of Parasitology، جلد ۱۷، شماره ۲، صفحات ۲۵۹-۲۶۷
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عنوان انگلیسی A Morinda royoc Root Extract and Fractions Exhibit Antigiardial Activity without Affecting Cell Viability
چکیده انگلیسی مقاله Background: The gastrointestinal parasite Giardia lamblia causes giardiasis. Its treatment with standard drugs produces side effects and improper treatment can generate resistant strains. New antigiardial compounds are needed. An analysis was done to identify the antigiardial activity of Morinda royoc, a plant used in traditional Mayan medicine to treat stomach and bowel pain. We aimed to assess the efficacy of M. royoc roots against G. lamblia and their effect on cells viability. Methods: A methanol extract was done of the root and then fractionated. The extract and fractions were tested in vitro on G. lamblia trophozoites and their effect on cell viability was quantified by flow cytometry. The active extract and fractions were analyzed by gas chromatography–mass spectrometry and high-performance liquid chromatography. Results: The hexane fraction exhibited potent activity against G. lamblia (IC50 = 0.08 µg/mL). Its principal component was an anthraquinone-type compound. None of the fractions were toxic to human promyelocytic leukemia, chronic myelogenous leukemia and human mononuclear cells. Conclusion: The medicinal plant M. royoc contains promising bioactive agents with antigiardial activity and deserves further research.
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نویسندگان مقاله | Carlos Quintal Novelo
High Specialty Medical Unit, Medical Center “Ignacio García Téllez”, Mexican Institute of Social Security, Mérida, Yucatán, Mexico


| Lia Valencia Chan
Yucatan Medical Research Unit, High Specialty Medical Unit, Medical Center “Ignacio García Téllez”, Mexican Institute of Social Security, Mérida, Yucatán, Mexico


| Antonieta Chávez González
Leukemic Stem Cells Lab, Oncology Research Unit, National Medical Center, Mexican Institute of Social Security, Mexico City, Mexico


| Jorge Rangel Méndez
Yucatan Medical Research Unit, High Specialty Medical Unit, Medical Center “Ignacio García Téllez”, Mexican Institute of Social Security, Mérida, Yucatán, Mexico


| Rosa Moo Puc
Yucatan Medical Research Unit, High Specialty Medical Unit, Medical Center “Ignacio García Téllez”, Mexican Institute of Social Security, Mérida, Yucatán, Mexico
نشانی اینترنتی https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3480
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