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Medical Journal of Islamic Republic of Iran، جلد ۲۹، شماره ۱، صفحات ۲۷۹-۲۸۷
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عنوان انگلیسی Reduction in ischemic brain injury following the administration of pentoxifylline after transient global ischemia/ reperfusion in a rat model
چکیده انگلیسی مقاله Background: It is well known that the hippocampus, the CA1 Pyramidal cells in particular, is selectively vulnerable during global cerebral ischemia. Recently, it is observed that pentoxifylline has a neuroprotective effect. This study explored the pharmacological relationship between ischemia-induced cell death of the hippocampus and the efficacy of a vasodilator agent (pentoxifylline) in the prevention of delayed neuronal death. Methods : This experimental study was performed on 4 groups: control, ischemia, experimental (200mg/kg pentoxifylline injection one hour prior to and one hour following ischemia) and vehicle (normal saline). Transient global ischemia was induced by bilateral common carotid arteries occlusion. To investigate the apoptotic bodies and caspase-3 activities as a central role in the execution phase of apoptosis, the brains were prepared for the TUNEL technique. Results : Pentoxifylline administration limited apoptosis and caspase-3 activities in rats’ hippocampi. Our data showed no significant difference between the number of apoptotic bodies in the CA1 region of the hippocampus in the control and pentoxifylline -treated groups (p= 0.994). The results of one- way ANOVA revealed that that ischemia significantly increased caspase-3 levels in the hippocampus (p< 0.05) however, the level of caspase-3 in pentoxifylline -treated rats was less than the ischemic group. Conclusion : These results suggest that the neuroprotective effect of pentoxifylline (200mg/kg) may be accompanied by a reduction in ischemic damage within the CA1 region of the hippocampus in rats subjected to transient global cerebral ischemia.
کلیدواژه‌های انگلیسی مقاله Cerebral ischemia, Reperfusion, Pentoxifylline, Hippocampus.
نویسندگان مقاله زهرا نادیا شریفی | zahra nadia sharifi
department of anatomy, islamic azad university, tehran medical branch, tehran, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

شبنم موثقی | shabnam movassaghi
department of anatomy, islamic azad university, tehran medical branch, tehran, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

فرزانه محمدزاده | farzaneh mohamadzadeh
departmentof anatomy, faculty of medicine, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

سارا سلیمانی اصل | sara soleimani asl
department of anatomy, school of medicine, hamadan university of medical sciences, hamadan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

باقر پورحیدر | bagher pourheydar
neurophysiology research center, department of anatomy, urmia university of medical sciences, urmia, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ارومیه (Urmia university of medical sciences)

مهدی مهدی زاده | mehdi mehdizadeh
cellular and molecular research center, faculty of advanced technologies in medicine, department of anatomy, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-835&slc_lang=en&sid=en
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