این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Blood and Cancer، جلد ۱۴، شماره ۲، صفحات ۸۵-۹۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی CAR-NK Cells: A Systematic Review of Emerging Alternative on Immunotherapy Against Leukemia
چکیده انگلیسی مقاله Background: Cancer is a public health emergency. It has a high mortality rate despite numerous studies on pharmaceutical therapies. Chimeric antigen receptor-natural killer (CAR-NK) cells are promising immunotherapy that could be used to treat cancer, especially leukemia. However, the evidence is still unclear. Thus, this systematic review aims to summarize the evidence regarding the use of CAR-NK cells as a therapy for leukemia. Method: This systematic review was conducted in accordance with the preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement guidelines. The literature search was done using PubMed, ProQuest, ScienceDirect, and EBSCOHost with "chimeric antigen receptor", "natural killer cell", and "leukemia" as the primary keywords until 20 March 2020. Data collection and extraction were done by three independent reviewers. Extending a risk-of-bias approach to address in-vitro studies for assessing the risk of bias was utilized in the quality assessment of the studies. Results: The search strategy identified 221 studies. Three relevant articles met our inclusion criteria. All the included studies had a low risk of bias. The main findings from available data were as follows: (a) cytotoxicities of CAR-NK cells were found highest in cell lines expressing antigen for CAR (CD19+ cancer cells) (b) CAR-NK cells had low cytotoxicities against cells that didn't express antigen for CAR (e.g. SR-91); (c) all studies did not result in aberrant growth of the transduced CAR-NK cells. Conclusion: The use of CAR-NK cells showed promising results in treating leukemia based on its cytotoxicity against CD19+ cancer cell lines.
کلیدواژه‌های انگلیسی مقاله Chimeric Antigen Receptors, leukemia, natural Killer Cells, cancer, systematic Review
نویسندگان مقاله | Alver Prasetya
School of Medicine and Health Sciences Atma Jaya Catholic University of Indonesia


| Robby Soetedjo
School of Medicine and Health Sciences Atma Jaya Catholic University of Indonesia


| Erlangga Saputra Arifin
School of Medicine and Health Sciences Atma Jaya Catholic University of Indonesia
نشانی اینترنتی http://ijbc.ir/browse.php?a_code=A-10-669-1&slc_lang=en&sid=1
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pediatric Hematology & Oncology
نوع مقاله منتشر شده مقاله مروری
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات