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Journal of Medical Microbiology and Infectious Diseases، جلد ۱۰، شماره ۲، صفحات ۷۵-۷۹
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عنوان انگلیسی Investigating Two-stage Tuberculin Skin Test for Screening Latent Tuberculosis Infections in Diabetic Patients: A Regional Study in Khorramabad, Iran
چکیده انگلیسی مقاله Introduction: latent tuberculosis infections (LTBI) are not detectable by a single-stage tuberculin test and maybe detected after repeating tests 7-21 days later. This phenomenon, called the boosting phenomenon, supports a two-stage test to identify false negatives in a single-stage test. The present study investigates the value of a two-stage tuberculin test in diabetic patients. Methods: We performed a tuberculin test for 195 diabetic patients. The patients with induration > 10 mm were subjected to a second tuberculin test 7-21 days later. Results: Of 195 patients, 115 came for measuring the tuberculin test induration, which was positive in 3 out of 115 patients (2.61%). Of the remaining 112 patients, 53 patients were subjected to the second test, and 38 patients came back for measuring the induration, which became positive in 4 (10.52%) patients. Conclusion: The increased LTBI rate from 2.61% to 10.52% following the second tuberculin test indicates a boosting phenomenon due to a delayed hypersensitivity reaction. Hence, patients with latent tuberculosis who had a false negative test in the first stage were identified.  
کلیدواژه‌های انگلیسی مقاله Tuberculosis, Latent tuberculosis, Type 2 diabetes mellitus, Two-stage tuberculin test, Boosting phenomenon
نویسندگان مقاله | Mahshad Mousavi
Student Research Committee, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran


| Nazanin Mousavi
Student Research Committee, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran


| Seyyed Amir Yasin Ahmadi
Student Research Committee, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran


| Mozhgan Kaviani
Department of Internal Medicine, School of Medicine, Lorestan University of Medical Science, Khorramabad, Iran
نشانی اینترنتی http://jommid.pasteur.ac.ir/browse.php?a_code=A-10-372-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Diagnostic/screening methods and protocols
نوع مقاله منتشر شده Original article
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