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Medical Journal of Islamic Republic of Iran، جلد ۲۹، شماره ۱، صفحات ۲۷۳-۲۷۸
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عنوان انگلیسی Plasma oxysterol level in patients with coronary artery stenosis and its changes in response to the treatment with atorvastatin
چکیده انگلیسی مقاله  Background: Considering the increasing incidence of coronary artery stenosis and its related complications, the importance of its etiology and inconsistent reports we aimed to determine the relationship between oxysterol, serum levels and severity of coronary atherosclerosis and effect of statins on oxysterol. Methods: A total of 85 patients referred to Taleghani Hospital, Tehran, Iran during 2011-2012 with coronary artery stenosis more than 75%, as determined by angiography, participated in the current study. Their demographic information and history of smoking and taking atorvastatin was carefully recorded. Two milliliters of venous blood was obtained from each patient. The serum oxysterol level of samples was measured using the enzyme-linked immunosorbent assay (ELISA) method. Statistical analysis was performed using SPSS v.19. Results: Eighty five patients completed the study. Mean age of patients was 64.4 years 51 (60%) were male 55 (68%) had acute coronary syndrome and 30 (32%) had chronic stable angina. Mean±SD of plasma level of oxysterol was 24.8±0.2 pmol/ml. The normal range of oxysterol level was 13pmol/ml. Mean±SD of plasma oxysterol level in patients under statin therapy was 24.4±2.1 pmol/ml. In patients without receiving statins, plasma oxysterol level was 26.38±1.6pmol/ml. Conclusion: Findings of the present study indicated significant correlation between serum oxysterol and severity of coronary artery stenosis. It also demonstrated that receiving atorvastatin is associated with significant reduction of plasma oxysterol level.
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نویسندگان مقاله امیرحمزه پردال | amir hamzeh pordal
faculty of nutrition and food technology, shahidbeheshti university of medical sciences, tehran, iran.


سید جواد hajmiresmail | seyed javad hajmiresmail
department of cardiology, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

محمد اسدپور پیرانفر | mohammad assadpoor piranfar
department of cardiology, taleghani hospital, school of medicine, shahid beheshti university of medical sciences, tehran. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

مهدی هدایتی | mehdi hedayati
head of cellular and molecular research center, research institute for endocrine sciences, shahid beheshti university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

مرجان عجمی | marjan ajami
department of food and nutrition policy and planning research, national nutrition and food technology research institute, faculty of nutrition and food technology, shahidbeheshti university of medical sciences, tehran, iran.
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-807&slc_lang=en&sid=en
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