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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۷، شماره ۱، صفحات ۳۹-۴۷
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عنوان انگلیسی Prognostic Value of the Expression of Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR-1) in Chronic Lymphocytic Leukemia
چکیده انگلیسی مقاله Background: The transmembrane receptor tyrosine kinase-like orphan receptor 1 (ROR1) has acted on the causation and sustentation of mature B cell lymphomagenesis for chronic lymphocytic leukemia (CLL) cells. The aim of this study was to show whether there is a relationship between the level of ROR1 surface expression in CLL cells and disease findings. Materials and Methods: The level of ROR1 cell surface expression was determined in accordance with the flow cytometric analysis of CLL patients at the first diagnosis time.  2 groups were formed according to the high and low ROR1 levels. The cut-off point to the ROR1 level was calculated for advanced-stage disease by using receiver operating characteristic (ROC) curves. A two-sided p-value < 0,05 was considered statistically significant. Results: 108 CLL cases with a median age of 60 were enrolled. The median percentage of ROR1 cell surface marker positivity in the CD5/CD19 positive leukemic cell was 62%. The CLL cases with high ROR1 levels have thrombocytopenia (p=0.042), anemia (p=0.028), and high beta 2 microglobulin value ≥3 mg/dL (p=0.002) and the need for first-line treatment (p=0.043). Conclusion: The poor prognostic parameters such as splenomegaly, anemia, higher beta 2 microglobulin levels, intermediate/advanced RAİ stage disease, and need for first-line treatment had associated high-level ROR 1 expression of our CLL patients. It needs to be investigated for its effect on predicting disease burden and aggressiveness with more comprehensive studies on ROR1 expression levels in CLL cases.
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نویسندگان مقاله | Aysun Senturk Yikilmaz
Department of Hematology, Bilkent City Hospital, Y&#x131;ld&#x131;r&#x131;m Beyaz&#x131;t University, Ankara, Turkey


| &#x15E;ule Bakanay
Department of Hematology, Bilkent City Hospital, Y&#x131;ld&#x131;r&#x131;m Beyaz&#x131;t University, Ankara, Turkey


| Duygu Avc&#x131;
Department of Hematology, Ankara Numune Training and Research Hospital, , Ankara, Turkey


| Sema Akinci
Department of Hematology, Atat&#xFC;rk Training and Research Hospital, Ankara, Turkey


| Mesude Falay
Department of Hematology, Ankara Numune Training and Research Hospital, , Ankara, Turkey


| G&#xFC;ls&#xFC;m &#xD6;zet
Department of Hematology, Ankara Numune Training and Research Hospital, Ankara, Turkey


| &#x130;mdat Dilek
Department of Hematology, Atat&#xFC;rk Training and Research Hospital, Ankara, Turkey
نشانی اینترنتی https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1649
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