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Avicenna Journal of Phytomedicine، جلد ۱۲، شماره ۵، صفحات ۵۱۴-۵۲۶
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عنوان انگلیسی Carvacrol attenuated neuroinflammation, oxidative stress and depression and anxiety like behaviors in lipopolysaccharide-challenged rats
چکیده انگلیسی مقاله Objective: The beneficial effect of carvacrol on neuroinflammation, oxidative damage of brain tissue, and depressive- and anxiety-like behaviors after lipopolysaccharide (LPS) administration were evaluated in rats.Materials and Methods: Vehicle (1% Tween 80), 1 mg/kg of LPS, and carvacrol (25, 50, or 100 mg/kg administered prior to LPS) were injected and behavioral and biochemical tests were done.Results: The results of forced swim test revealed that carvacrol attenuated immobility time and increased activity and climbing times (p< 0.05 to p< 0.001). The results of elevated plus maze also revealed that treatment by carvacrol prolonged the open arms time and entries and decreased the time and entries in the closed arms (p< 0.05 to p< 0.01). Carvacrol enhanced crossing, time, and traveled distance in the central segment of the open field and increased total crossing and distance while attenuating the peripheral zone time (p< 0.05 to p< 0.001). All doses of carvacrol attenuated TNF- α (tumor necrosis factor α) and NO (nitric oxide) in the brain (p< 0.01 to p< 0.001). The 50 and the 100 mg/kg doses of carvacrol decreased malondialdehyde (p< 0.001 for both), and the 100 mg/kg dose of carvacrol increased the content of the thiol (p< 0.001).Conclusion: In conclusion, carvacrol improved the behavioral consequences of LPS challenge and attenuated neuroinflammation and brain tissue oxidative stress in rats.
کلیدواژه‌های انگلیسی مقاله Inflammation, Anxiety, Depression, Carvacrol, Oxidative stress
نویسندگان مقاله | Hossein Salmani
Student Research Committee, Jiroft University of Medical Sciences, Jiroft, Iran


| Zahra Hakimi
Faculty of Medicine, Ghalib University, Herat, Afghanistan


| Zohre Arab
Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Narges Marefati
Department of Physiology and Medical Physics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran


| Mohammad Reza Mahdinezhad
Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Abolfazl RezaeiGolestan
Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Farimah Beheshti
Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.


| Mohammad Soukhtanloo
Department of Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| AmirAli Mahnia
Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Mahmoud Hosseini
Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_20005.html
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