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Iranian Journal of Nuclear Medicine، جلد ۳۱، شماره ۱، صفحات ۱۰۵-۱۰۸
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عنوان انگلیسی Dramatic cessation of gross sustained treatment resistant hematuria after [177Lu]Lu-PSMA-617 therapy: A case report
چکیده انگلیسی مقاله We report a patient with locally invasive metastatic castration resistant prostate adenocarcinoma, which had massive invasion to the bladder and caused frequent gross hematuria. The patient had received more than 10 units of packed cell at the time he was referred for [177Lu]Lu-PSMA-617 therapy, but despite frequent transfusions his serum hemoglobin level had been under 8 g/dl most of the time. He had received first generation androgen deprivation therapy (ADT) from 3 years previously and the second generation since 1 year ago and had undergone multiple procedures for cessation of hematuria, such as multiple cystoscopies, bladder irrigations and angioembolizations. We performed [99mTc]Tc-PSMA whole body and SPECT/CT scan, which demonstrated a large PSMA avid prostate mass invading the urinary bladder wall. All components of the locally invasive tumor were present demonstrating high PSMA avidity, so he was scheduled for [177Lu]Lu-PSMA-617 therapy. One week after the diagnostic scan, therapeutic dose of [177Lu]Lu-PSMA-617 was administered. The patient reported no hematuria 4 days after the [177Lu]Lu-PSMA-617 administration. In the follow up, no recurrent hematuria was reported, too. The PSA level also declined from 40.5 ng/ml to 18.7 ng/ml, 1 month after the first treatment.
کلیدواژه‌های انگلیسی مقاله Castration resistant prostate adenocarcinoma, Androgen deprivation therapy, Hematuria, [177Lu]Lu-PSMA-617
نویسندگان مقاله Hamid Reza Ghorbani |
Kidney Transplant Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Salman Soltani |
Kidney Transplant Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Vahid Roshanravan |
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Kamran Aryana |
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Atena Aghaee |
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

نشانی اینترنتی http://irjnm.tums.ac.ir/article_40045_e1e6be9e9856a6e9fded8990fb75c9de.pdf
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