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Iranian Journal of Basic Medical Sciences، جلد ۲۵، شماره ۹، صفحات ۱۰۵۹-۱۰۶۸
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عنوان انگلیسی Major pathogenic Clostridia in human and progress toward the clostridial vaccines
چکیده انگلیسی مقاله The Clostridium genus is composed of a large spectrum of heterogeneous bacteria. They are Gram-positive, mostly mesophilic, and anaerobic spore-forming strains. Clostridia are widely distributed in oxygen-free habitats. They are found principally in the soil and intestines of ruminants as normal flora, but also are the cause of several infections in humans. The infections produced by important species in humans include botulism, tetanus, pseudomembranous colitis, antibiotics-associated diarrhea, and gas gangrene. Immunization with toxoid or bacterin-toxoid or genetically modified or other vaccines is a protective way against clostridial infection. Several experimental or commercial vaccines have been developed worldwide. Although conventional vaccines including toxoid vaccines are very important, the new generation of vaccines is an effective alternative to conventional vaccines. Recent advances have made it possible for new vaccines to increase immunogenicity. This review discusses briefly the important species of clostridia in humans, their toxins structure, and vaccine development and usage throughout the world.
کلیدواژه‌های انگلیسی مقاله Botulinum, Clostridium, Difficile, Tetani, Toxin, Vaccine
نویسندگان مقاله | Lida Abdolmohammadi Khiav
Department of Anaerobic Vaccine Research and Production, Specialized Clostridia Research Laboratory, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization, Karaj, Iran


| Azadeh Zahmatkesh
Department of Anaerobic Vaccine Research and Production, Specialized Clostridia Research Laboratory, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization, Karaj, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_20733.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Review Article
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