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Iranian Journal of Veterinary Science and Technology، جلد ۱۳، شماره ۲، صفحات ۳۷-۴۵
عنوان فارسی شواهد تقابل سیستم های کانابینوئیدرژیک و دوپامینرژیک با گیرنده های MC۳/ MC۴ ملانوکورتینی در تنظیم اخذ غذای در جوجه های نوزاد
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عنوان انگلیسی Evidence for an interaction between cannabinoidergic and dopaminergic systems with melanocortin MC3/ MC4 receptors in regulating food intake of neonatal chick
چکیده انگلیسی مقاله The current study aimed to see how the central dopaminergic and cannabinoidergic mechanisms affect melanocortin-induced food intake in the neonatal layer chickens. In this regard, 9 experiments were designed. In experiment 1, chicks injected with control solution, MTII (2.5, 5, and 10 ng). In experiment 2, control solution, L-DOPA (125 nmol), MTII (10 ng), and L-DOPA + MTII were applied to the birds. Experiments 3-9 were similar to experiment 2, except birds injected with 6-OHDA (150 nmol), SCH23390 (5 nmol), AMI-193 (5 nmol), NGB2904 (6.4 nmol), L-741,742 (6 nmol), SR141716A (6.25 µg), and AM630 (5 µg) instead of L-DOPA. Then, cumulative food intake was recorded at 30, 60, and 120 min following injection. According to the results, in comparison with the control group, dose-dependent hypophagia was observed in 3-h food-deprived neonatal layer chickens following ICV injection of MTII (2.5, 5, and 10 ng) (P< 0.05). ICV injection of L-DOPA and SR141716A increased hypophagia induced by MTII in chickens (P< 0.05), while 6-OHDA greatly suppressed MTII- induced hypophagia (P< 0.05). In addition, SCH23390 and AMI-193 greatly weakened the MTII-induced hypophagia in neonatal layer chickens (P< 0.05). However, NGB2904, L-741742 and AM630 had no role on hypophagia induced by MTII (P>0.05). These results demonstrated that melanocortin-induced hypophagia in the neonatal layer chickens is likely mediated by D1, D2, and CB1 receptors.
کلیدواژه‌های انگلیسی مقاله Dopamine, Cannabinoid, Melanocortin, food intake, Layer chicken
نویسندگان مقاله Mohammad Bameri |
Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Morteza Zendedel Kheybari |
Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

Bita Vazir |
Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Ahmad Asghari |
Department of Clinical Science, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Negar Panahi |
Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran.

نشانی اینترنتی https://ijvst.um.ac.ir/article_40556_a581254cfc2dd5a9de53b984955a8d18.pdf
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