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Journal of Particle Science and Technology، جلد ۸، شماره ۱، صفحات ۱۷-۲۳
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عنوان انگلیسی A new method for the preparation of pure acamprosate calcium with a micron particle size
چکیده انگلیسی مقاله Considering that preparing microparticle drugs enhances their solubility and bioactivity, it is the pharmaceutics’ interest to have more information about the drug’s particle size; hence, it is essential to study a drug’s particle size and morphology. So far, no work has been done on the particle size of acamprosate calcium. In this work, micronized acamprosate calcium was first prepared, then its water solubility was investigated. To this aim, acamprosate calcium was synthesized from 1,3-propane sultone through two-step reactions. The resulting powder was then micronized using Triton-X-100 using the in situ micronization method. The resulting micronized particles were found to be highly pure (99.7 %). The micronized acamprosate calcium's particle size was less than 10 µm. Kinetic solubility studies showed that micronized acamprosate calcium's water solubility had improved compared to bulk particles of acamprosate calcium.
کلیدواژه‌های انگلیسی مقاله Acamprosate calcium, Micronized drugs, Solubility, In situ micronization, Triton-X-100
نویسندگان مقاله Fatemeh Mobayyen Jarihani |
Department of Chemical Technologies, Iranian Research Organization for Science and Technology, Tehran, Iran

Farajollah Mohannazadeh |
Department of Chemical Technologies, Iranian Research Organization for Science and Technology, Tehran, Iran

نشانی اینترنتی https://jpst.irost.ir/article_1207_b9a68148e6a7bef0a5288fa132284366.pdf
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