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Iranian Journal of Public Health، جلد ۵۲، شماره ۳، صفحات ۶۱۲-۶۲۱
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عنوان انگلیسی Prevalence of High-Risk Human Papillomavirus Types and Their Association with Cervical Squamous Cell Carcinoma, and High- and Low-Grade Squamous Intraepithelial Lesions in Turkish Women
چکیده انگلیسی مقاله Background: This study aimed to investigate human papillomavirus (HPV) type prevalence in our region and the relationship between uterine cervical HPV types and squamous cell carcinoma (SCC)/intraepithelial lesions. Methods: HPV test results were obtained from patient file archives of the Gynecology and Obstetrics Clinic. Pathology report results were obtained from the digital records of the Pathology Laboratory and the patient file archives of the Gynecology and Obstetrics Clinic in 2018. Results: The most frequently detected was HPV16 (29.2%), followed by HPV51 (13.1%), HPV56 (11%), HPV31 (9.2%), HPV52 (8.4%), and HPV68 (8.2%). HPV16 was positive in 50% of patients diagnosed with SCC, 54.9% of patients with HSIL, 27% of patients with LSIL, and 25% of cases diagnosed as benign (P< 0.001). HPV18 was positive in 25% of patients diagnosed with SCC, 11% of patients with HSIL, 4.7% of patients with LSIL, and 5.2% of cases diagnosed as benign (P=0.019). Conclusion: The most frequent hrHPV genotype was HPV16, followed by HPV51, HPV 56, and HPV 31. There is an increase in the frequency of HPV51 and HPV56. HPV51, not included in HPV vaccines and is the second most frequent, should be included in these vaccines. In addition, although the frequency of HPV18 has decreased, HSIL and SCC generation is still high together with HPV16.
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نویسندگان مقاله | Ta&#x15F;k&#x131;n Erkin&#xFC;resin
Department of Pathology, Bursa Yuksek Ihtisas Training and Research Hospital, University of Health Sciences, Bursa, Turkey


| Esra Kartal
Department of Gynecology and Obstetrics, Bursa Yuksek Ihtisas Training and Research Hospital, University of Health Sciences, Bursa, Turkey


| Emin &#xDC;st&#xFC;nyurt
Department of Gynecology and Obstetrics, Bursa Yuksek Ihtisas Training and Research Hospital, University of Health Sciences, Bursa, Turkey


| Hakan Demirci
Department of Family Medicine, Bursa Yuksek Ihtisas Training and Research Hospital, University of Health Sciences, Bursa, Turkey


| Asuman Kilit&#xE7;i
Department of Pathology, Faculty of Medicine, K&#x131;r&#x15F;ehir Ahi Evran University, K&#x131;r&#x15F;ehir, Turkey


| Binnur &#xD6;nal
Department of Pathology, Faculty of Medicine, University of D&#xFC;zce, D&#xFC;zce, Turkey
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/26872
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