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Iranian Journal of Parasitology، جلد ۱۸، شماره ۱، صفحات ۶۶-۷۵
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عنوان انگلیسی Synthesis and Clinical Examination of Novel Formulations of Ivermectin, Albendazole and Niclosamide for the Treatment of Equine Gastrointestinal Helminthoses
چکیده انگلیسی مقاله Background: This study aimed to develop new complex preparations of ivermectin, niclosamide and albendazole based on solid-phase mechanochemical technology, and to evaluate their efficacy against equine nematodosis and cestodosis. Methods: Novel formulation of antiparasitic paste were prepared using joint mechanochemical treatment of ivermectin (0.2 mg/kg bodyweight; BW), niclosamide (10 mg/kg BW) and albendazole (3, 5, 10 mg/kg BW) substances with polyvinylpyrrolidone and arabinogalactan. For the evaluation of activity of different doses of formulations against gastrointestinal tract helminths a total of 151 adult horses of the Novoaltai breed weighing 450–500 kg naturally infected with strongyles (>150 egg per gram of faeces, EPG), Parascaris spp. (>20 EPG) and Anoplocephala spp. (>10 EPG) were selected. Antiparasitic pastes were orally fed to the horses and faecal egg count reduction counts were compared prior to and 14 days after the treatment. Results: Pastes with mechanically modified ivermectin showed 91.4–100% efficacy against strongyles and Parascaris. Pastes with modified albendazole and niclosamide were also effective against Anoplocephala in all tested dosages i.e. 78.6–100%. In particular, treatment with two formulations containing i) 0.2 mg ivermectin, 10 mg albendazole, 10 mg niclosamide, and ii) 0.2 mg ivermectin, 3 mg albendazole showed 100% efficacy against strongyles, Parascaris and Anoplocephala. Conclusion: Solid-phase mechanochemical technology could be applied in equine anthelminthics production. It is suggested that future studies focus on plasma concentration-time profile of these highly effective pastes.
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نویسندگان مقاله | Victor Marchenko
Federal Altai Scientific Center for Agrobiotechnology, Town 35, Barnaul, Russia


| Salavat Khalikov
A.N. Nesmeyanov Institute of Organoelement Compounds Russian Academy of Science, Moscow, Russia


| Ivan Biryukov
Federal Altai Scientific Center for Agrobiotechnology, Town 35, Barnaul, Russia


| Elena Efremova
Siberian Federal Scientific Centre of Agro-Bio Technologies RAS, Krasnoobsk, Russia


| Mikhail Ilyin
A.N. Nesmeyanov Institute of Organoelement Compounds Russian Academy of Science, Moscow, Russia


| Alireza Sazmand
Department of Pathobiology, Faculty of Veterinary Science, Bu-Ali Sina University, 6517658978 Hamedan, Iran
نشانی اینترنتی https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3678
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