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Middle East Journal of Digestive Diseases، جلد ۱۵، شماره ۲، صفحات ۱۰۷-۱۱۵
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عنوان انگلیسی Determinants of Short-term Mortality in Liver Cirrhosis with Acute Kidney Injury: A Prospective Observational Study
چکیده انگلیسی مقاله Background : Acute kidney injury (AKI) occurs in 20-50% of patients with cirrhosis and is associated with a poor prognosis. Aim : To identify the baseline factors affecting mortality in these patients at 30 and 90 days. Methods : We enrolled 117 patients with cirrhosis and AKI and followed them up prospectively. Results : Distribution of International club of ascites AKI stages was: 26 (22.03%) stage 1, 59 (50%) stage 2, and 33 (28%) stage 3. Mortalities at 30 and 90 days were 27 (22.8%) and 33 (27.9%) respectively. On multivariate analysis, variables affecting mortality at 30 days were serum creatinine level >2 mg% at 48 hours after AKI development (adjusted OR 7.93, P=0.02) and leucocytosis (total leucocyte count>11,000/mm 3 ) at admission (adjusted OR 6.54, P=0.002). Only leucocytosis at admission was a predictor of 90 days mortality (adjusted OR 4.76, P=0.01). Though not statistically significant, patients not responding to standard medical treatment had 3 times higher mortality at 30 days, while the maximum AKI stages (2 and 3) had eight times higher mortality at 90 days. Conclusion : In cirrhosis, AKI increases short-term mortality. High serum creatinine at 48 hours affects mortality at 30 days, while leucocytosis at baseline predicts mortality at 30 and 90 days. Progression to a higher AKI stage impacts prognosis.
کلیدواژه‌های انگلیسی مقاله Acute kidney injury,Chronic liver disease,Hepatorenal syndrome
نویسندگان مقاله | Shubham Jain
Assistant Professor, Department of Gastroenterology, Topiwala National Medical College and BYL Nair Charitable Hospital, Dr. A.L Nair Road, Mumbai- 400 008, Maharashtra, India


| Suhas Udgirkar
Assistant Professor, Department of Gastroenterology, Topiwala National Medical College and BYL Nair Charitable Hospital, Dr. A.L Nair Road, Mumbai- 400 008, Maharashtra, India


| Pravin M Rathi
Assistant Professor, Department of Gastroenterology, Topiwala National Medical College and BYL Ch Hospital, Dr. A.L Nair Road, Mumbai- 400 008, Maharashtra, India


| Ravi Thanage
Assistant Professor, Department of Gastroenterology, Topiwala National Medical College and BYL Nair Charitable Hospital, Dr. A.L Nair Road, Mumbai- 400 008, Maharashtra, India.


| Prasanta Debnath
Assistant Professor, Department of Gastroenterology, Topiwala National Medical College and BYL Nair Charitable Hospital, Dr. A.L Nair Road, Mumbai- 400 008, Maharashtra, India.


| Parmeshwar Junare
Assistant Professor, Department of Gastroenterology, Topiwala National Medical College and BYL Nair Charitable Hospital, Dr. A.L Nair Road, Mumbai- 400 008, Maharashtra, India


| Sanjay Chandnani
Associate Professor, Department of Gastroenterology, Topiwala National Medical College and BYL Nair Charitable Hospital, Dr. A.L Nair Road, Mumbai- 400 008, Maharashtra, India


| Qais Q Contractor


نشانی اینترنتی http://mejdd.org/index.php/mejdd/article/view/2673
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