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International Journal of Radiation Research، جلد ۲۱، شماره ۳، صفحات ۳۶۱-۳۶۷
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عنوان انگلیسی 68-Ga-labeled NODAGA-RGD-BBN heterodimer peptide as a novel radiotracer for dual integrin and GRPR-targeted tumor imaging
چکیده انگلیسی مقاله Background: Due to the excellent physical and biochemical characteristics of 68Ga, 68Ga-1,4,7-triazacy–clononane–glutaric acid– 4,7 acetic acid- arginyl-glycyl-aspartic acid- bombesin (68Ga-NODAGA-RGD-BBN) was prepared as a new positron emission tomography (PET) imaging agent, and afterward, the preclinical evaluation of this labeled peptide was studied. Materials and Methods: 68Ga radioisotope was extracted from a 68Ge/68Ga generator with high radionuclide, chemical and radiochemical purities. Then; the 68Ga-NODAGA-RGD-BBN radiolabeled complex was prepared at optimized conditions. The stability of the complex was evaluated in phosphate-buffered saline (PBS) for at least 2 h. Cell studies of the radiolabeled peptide were also assessed on the gastrin releasing peptide receptor (GRPR)-expressing cell line. Finally; the biodistribution and whole-body scan imaging study of 68Ga-NODAGA-RGD-BBN was studied in normal and tumor-bearing mice. Results: The biodistribution and whole-body scan imaging of the radiolabeled compound on GRPR-expressing tumor-bearing mice demonstrated the high uptake in the tumor site at all post-injection intervals.  The biodistribution results also demonstrated the major excretion route of the complex is the urinary tract. Conclusions: 68Ga-NODAGA-RGD-BBN shows high potential for PET imaging of patients with GRPR-expressing tumors; however, more biological studies are still needed.
کلیدواژه‌های انگلیسی مقاله GRPR positive tumors, radiolabeling, heterodimer peptide, PET imaging.
نویسندگان مقاله | N. Amraee
Medical Radiation Engineering Department, Science and Research Branch, Islamic Azad University (IAU), Tehran, Iran


| B. Alirezapour
Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran


| M. Hosntalab
Medical Radiation Engineering Department, Science and Research Branch, Islamic Azad University (IAU), Tehran, Iran


| A. Hadadi
Medical Radiation Engineering Department, Science and Research Branch, Islamic Azad University (IAU), Tehran, Iran


| H. Yousefnia
Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran
نشانی اینترنتی http://ijrr.com/browse.php?a_code=A-10-1-1053&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
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