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Iranian Journal of Nuclear Medicine، جلد ۲۵، شماره ۱، صفحات ۱۱-۱۶
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عنوان انگلیسی Development of 153Sm/177Lu-EDTMP as a possible therapeutic complex
چکیده انگلیسی مقاله Introduction:Targeted radionuclide therapy (TRT) has been demonstrated to be an effective therapeutic tool in patients with disseminated bone metastasis. TRT is generally performed with a single radionuclide. In this study we investigated the feasibility of combined TRT with a high-energy beta emitter (153Sm) and a low energy beta emitter (177Lu) in wistar rats. Methods: The cocktail complex of 153Sm/177Lu-EDTMP was prepared. To determine the effect of metal-to-ligand (Me:EDTMP) molar ratio on labeling yield, several complex were analyzed after changing Me:EDTMP molar ratio from 1:1 to 1:50. 153Sm/177Lu-EDTMP was administered intravenously through the tail vein of wistar rats. Biodistribution data were collected at 2 hours to 7 day post injection and scintigraphic images were taken at 24 hours and 1, 2 week after administration of radiopharmaceutical. Results: The results revealed high skeletal uptake (3.5% and 3.4% ID/g at 24 hours post injection for 153Sm and 177Lu, respectively) with rapid blood clearance and minimal uptake in any of the major organs. Scintigraphic images verified high skeletal uptake. Conclusion: Our results indicate that the combination of 153Sm and 177Lu is feasible and safe. This study suggests that the combination of different radionuclides with different radiation energies and half-life, such as 153Sm and 177Lu, could be advantageous in patients with tumoral lesions of different sizes.
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نویسندگان مقاله حسن رنجبر |
radiopharmaceutical research and development lab rrdl , nuclear science and technology research institute nstri , p.o. box 14395-836, tehran, iran

علی بهرامی سامانی | bahrami samani
radiopharmaceutical research and development lab rrdl , nuclear science and technology research institute nstri , p.o. box 14395-836, tehran, iran

داود بیکی |
research center for nuclear medicine, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد قنادی مراغه | ghannadi maragheh
radiopharmaceutical research and development lab rrdl , nuclear science and technology research institute nstri , p.o. box 14395-836, tehran, iran

نشانی اینترنتی http://irjnm.tums.ac.ir/article_23082_cd95c904a5278f02e7348478a5848deb.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/57/article-57-279091.pdf
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زبان مقاله منتشر شده en
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