این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Blood and Cancer، جلد ۱۵، شماره ۲، صفحات ۸۰-۸۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی NLR, PLR, and HPR as novel diagnostic biomarkers for Acute Lymphoblastic Leukemia
چکیده انگلیسی مقاله Background: Acute lymphoblastic leukemia (ALL) causes uncontrolled cell proliferation and prevents normal cell differentiation at any stage of hematopoiesis. Therefore, timely diagnosis and treatment are very important. Complete blood count (CBC) can be a simple, but valuable initial test to diagnose ALL. In this study, we investigated the diagnostic value of hematological parameters, including Platelet to lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and hemoglobin to Platelet ratio (HPR) indices in ALL. Methods: In this study, 54 ALL patients (Mean ages: 5.29) and 58 healthy controls (Mean ages: 5.53) were evaluated. They were compared in terms of hematological parameters, including PLR, NLR, and HPR; cytogenetic and immunophenotypes were also analyzed. Result: In the analysis of hematological factors between the studied groups, all indices except lymphocytes showed a statistically significant relationship (P-Value ˂0.05). In terms of hematological factors, only WBC and ESR were statistically significant between the B-ALL and T-ALL groups (P-Value ˂0.05). The ROC curve was generated to select the appropriate cut-off values for NLR, PLR, and HPR based on analysis. NLR and PLR have cut-off values of 0.50 and 62.24, respectively; they are good biomarkers to distinguish ALL individuals from normal people. HPR value was significant between case and control groups, but it was not a suitable indicator for distinguishing patients from the control group. Conclusion: CBC is a simple and valuable test for early detection of ALL, and the new PLR and NLR markers are good hematologic markers for ALL diagnoses.
کلیدواژه‌های انگلیسی مقاله Acute lymphoblastic leukemia, Complete blood count, Diagnostic biomarker, NLR, PLR.
نویسندگان مقاله | Bahareh Moghimian
Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran


| Ahmad Jafari-joshaghan
Department of Pathology, Faculty of Medicine, University of Medical Sciences, Mashhad, Iran


| Hossein ayatollahi
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Fatemeh Shams
Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Iranian Blood Transfusion Organization (IBTO), Tehran, Iran


| Narjes Soltani
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Fatemeh Ahmadpour
Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran


| Sepideh Shakeri
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Mohammadreza Javan
Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Iranian Blood Transfusion Organization (IBTO), Tehran, Iran
نشانی اینترنتی http://ijbc.ir/browse.php?a_code=A-10-976-1&slc_lang=en&sid=1
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pediatric Hematology & Oncology
نوع مقاله منتشر شده پژوهشی
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات