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Iranian Journal of Public Health، جلد ۵۲، شماره ۸، صفحات ۱۶۱۳-۱۶۲۵
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عنوان انگلیسی Oxidative Stress and DNA Damages Induced by Occupational Exposure to Asbestos: A Systematic Review
چکیده انگلیسی مقاله Background: Asbestos is one of the most important environmental and occupational carcinogens. Nevertheless, the mechanisms by which asbestos fiber exposure causes chronic diseases are not fully understood. We performed the first systematic review on the epidemiological evidence to examine the association between occupational exposure to asbestos and oxidative stress and DNA damage. Methods: In this systematic review study, the PubMed and Scopus databases were searched for English-language publications. Eleven cross-sectional studies were included in the systematic review. A literature search was conducted by the main keywords including "Asbestos", "crocidolite", "chrysotile", "amphibole", "amosite", "Oxidative Stress", "DNA Damage", and "DNA injury". To evaluate the quality of studies, the "Newcastle-Ottawa Quality Assessment Scale" (NOS) was used. Results: Overall, 1235 articles were achieved by searching in databases. Finally, by considering the inclusion, and exclusion criteria, 11 articles were conducted for this study. These studies were published between 1986 and 2020. Oxidative stress and DNA damage can occur in exposure to asbestos. Among various biomarkers, 8-OHdG is the best. The analysis of 8-oxodG in asbestos workers can help identify subjects with a higher level of genotoxic damage. Conclusion: This systematic review suggests that oxidative stress and DNA damage are two main outputs of asbestos exposure. Therefore, oxidative stress and DNA damage biomarkers can be used for identifying subjects at higher risk of cancer. These findings support policy initiatives aimed at detecting and eliminating asbestos fiber exposure and preventing potential health hazards in occupational settings.
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نویسندگان مقاله | Mirghani Seyed Someah
Department of Natural Resources and Environment, Science and Research Branch, Islamic Azad University, Tehran, Iran


| Farideh Golbabaei
1. Department of Natural Resources and Environment, Science and Research Branch, Islamic Azad University, Tehran, Iran 2. Department of Occupational Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Reza Arjomandi
Department of Natural Resources and Environment, Science and Research Branch, Islamic Azad University, Tehran, Iran


| Farzam Babaei Semiromi
Department of Natural Resources and Environment, Science and Research Branch, Islamic Azad University, Tehran, Iran


| Ali Mohammadi
Department of Natural Resources and Environment, Science and Research Branch, Islamic Azad University, Tehran, Iran
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/28441
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