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The Archives of Bone and Joint Surgery، جلد ۱۱، شماره ۹، صفحات ۵۶۵-۵۶۹
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عنوان انگلیسی Matrix Metalloproteases 8 Polymorphism as Risk Factor for Rotator Cuff Tear
چکیده انگلیسی مقاله Objectives: Rotator Cuff Tear (RCT) is a multifactorial disease, but an important one is the increased collagen degradation that would lead to a higher chance of tear. MMP-8 is a protein that degrades type I collagen, and it is known that MMP-8 has a polymorphism in which a T allele in the gene promoter region increases its transcription activity. This study aims to investigate the association between MMP -8 polymorphism g.-799 C>T (rs11225394) and RCT.Methods: To do that, we collected DNA samples from buccal epithelial cells of 128 patients (separated into RCT group and control group in a proportion 1:1) and genotyped the DNA using PCR. The statistical analyses were done using the ARLEQUIN Version 2.0, and the data normality was tested with the Shapiro-Wilk test.Results: The results showed a significantly higher frequency of T/T genotype in the test group (29% in the control group and 39% in the test group, p=0.0417), and that would represent a risk factor for increased collagen degradation.Conclusion: The MMP-8 g.-799 C>T (rs11225394) SNP was associated with RCT. With the description of a new risk factor, future research can be done to analyze how to prevent RCT or develop new treatment strategies since the disease's failure index is currently high. Level of evidence: II
کلیدواژه‌های انگلیسی مقاله Genetic polymorphism, Metalloproteases, Risk Factor, Rotator cuff tear
نویسندگان مقاله | Nathali Cavascan
Department of Cell Biology, University Federal of Paraná, Curitiba, PR, Brazil


| Jorge Assunção
Department of Orthopedics and Traumatology, University of São Paulo, São Paulo, SP, Brazil


| Alexandre Godoy-Santos
Department of Orthopedics and Traumatology, University of São Paulo, São Paulo, SP, Brazil


| Arnaldo Ferreira Neto
Department of Orthopedics and Traumatology, University of São Paulo, São Paulo, SP, Brazil


| Maria Cristina Santos
Department of Cell Biology, University Federal of Paraná, Curitiba, PR, Brazil
نشانی اینترنتی https://abjs.mums.ac.ir/article_22830.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده RESEARCH PAPER
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