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Research in Pharmaceutical Sciences، جلد ۱۸، شماره ۵، صفحات ۵۶۶-۵۷۹
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عنوان انگلیسی PCL/Agarose 3D-printed scaffold for tissue engineering applications: fabrication, characterization, and cellular activities
چکیده انگلیسی مقاله Background and purpose: Biomaterials, scaffold manufacturing, and design strategies with acceptable mechanical properties are the most critical challenges facing tissue engineering. Experimental approach: In this study, polycaprolactone (PCL) scaffolds were fabricated through a novel three-dimensional (3D) printing method. The PCL scaffolds were then coated with 2% agarose (Ag) hydrogel. The 3D-printed PCL and PCL/Ag scaffolds were characterized for their mechanical properties, porosity, hydrophilicity, and water absorption. The construction and morphology of the printed scaffolds were evaluated via Fourier-Transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The attachment and proliferation of L929 cells cultured on the scaffolds were investigated through MTT assay on the cell culture study upon the 1 st , 3 rd , and 7 th days. Findings/Results: The incorporation of Ag hydrogel with PCL insignificantly decreased the mechanical strength of the scaffold. The presence of Ag enhanced the hydrophilicity and water absorption of the scaffolds, which could positively influence their cell behavior compared to the PCL scaffolds. Regarding cell morphology, the cells on the PCL scaffolds had a more rounded shape and less cell spreading, representing poor cell attachment and cell-scaffold interaction due to the hydrophobic nature of PCL. Conversely, the cells on the PCL/Ag scaffolds were elongated with a spindle-shaped morphology indicating a positive cell-scaffold interaction. Conclusion and implications: PCL/Ag scaffolds can be considered appropriate for tissue-engineering applications.
کلیدواژه‌های انگلیسی مقاله Agarose,Polycaprolactone,3D printing,Tissue engineering.
نویسندگان مقاله | Sho’leh Ghaedamini
Department of Biomaterials, Nanotechnology and Tissue Engineering, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.


| Saeed Karbasi
Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.


| Batool Hashemibeni
3Cellular and Molecular Research Center, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran.


| Ali Honarvar
Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.


| Abbasali Rabiei


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/2213
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نوع مقاله منتشر شده Original Article
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