این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Medical Journal of Islamic Republic of Iran، جلد ۲۹، شماره ۱، صفحات ۴۲-۴۸
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عنوان انگلیسی Sequence-based genotyping of hepatitis B virus in general popula-tion
چکیده انگلیسی مقاله Background: Hepatitis B Virus (HBV) causes acute and chronic liver disease worldwide. HBV has eight genotypes (A to H) which is the reflection of its genome with their characteristic geographical distribution. Each genotype could have different pathogenic and therapeutic characteristics. There have been few records on HBV genotyping in general population from our region. This study aimed to determine hepatitis B genotypes using sequencing in the general population of Shahrekord, a Southwestern region of Iran. Methods: A total of 3000 serum samples (cluster sampling method) were enrolled from general population tested for HBsAg using ELISA. Using appropriate extraction kit, HBV DNA was extracted from HBsAg positive samples and each was subjected to nested PCR for detection of HBV DNA. Finally, using sequencing, the samples were used for HBV genotyping. Data were analyzed by SPSS 19 using descriptive statistics, chi square, and Fisher’s exact test. P-value < 0.05 was considered as the level of significance. Results: Out of 3000 serum samples, 40 (1.3%) were positive for HBsAg. HBV DNA was detected in 10 out of 40 (25%) of the samples studied. Genotype D was the predominant HBV type found in all of these 10 HBV positive samples. Conclusion: Genotype D is probably the predominant HBV type in our region.
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نویسندگان مقاله علی کریمی | ali karimi
medicinal research center, shahrekord university of medical sciences, shahrekord, iran.


معصومه معزی | ma soumeh moezzi
department of community medicine, shahrekord university of medical sciences, shahrekord, iran.


رضا ایمانی | reza imani
department of infectious diseases, shahrekord university of medical sciences, shahrekord, iran.
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-775&slc_lang=en&sid=en
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زبان مقاله منتشر شده en
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