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Iranian Journal of Parasitology، جلد ۱۸، شماره ۳، صفحات ۳۸۲-۳۸۹
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عنوان انگلیسی Transcriptome Profiling of Male Adult Angiostrongylus cantonensis
چکیده انگلیسی مقاله Background: The pathogen of angiostrongyliasis is the parasite Angiostrongylus cantonensis, and the transcriptome profiling of the male adult was unclear. We aimed to understand how the male adults adapt, so the expression profile of A. cantonensis adult males was analyzed. Methods: In order to improve the understanding of the transcriptome of adult males, RNA from three groups of male adult A. cantonensis was extracted and reverse transcribed to construct cDNA libraries. After sequencing, annotation of unigenes and transcripts was performed by querying the NR (Non-Redundant Protein Sequence Database), GO (Gene Ontology) and COG/ KOG (Clusters of Orthologous Groups of proteins/euKaryotic Ortholog Groups) databases. Results: For each group of adults, 43,260,894 raw reads and 43,200,341 clean reads were obtained. After successful assembly, 87,649 unigenes and 146,895 transcripts were obtained. Annotation of the unigenes and transcripts was identical and male adults expressed a series of genes encoding proteins specific to the male gender at the adult stage, such as proteins involved in energy metabolism, energy synthesis and transport. Expression of the ribosome pathway suggests a relationship with the physical activities during the adult male stage. Conclusion: The transcriptome analysis is a good reference to understand further the expression profile of male adult A. cantonensis.
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نویسندگان مقاله | Guo Yue
School of Medicine, Huzhou University & Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, Huzhou, Zhejiang, China


| Yu Liang Cao
Emergency Department, South Taihu Hospital, Gangnan Road 1566, Huzhou, Zhejiang, China


| Dong Ying
School of Medicine, Huzhou University & Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Prov-ince, Huzhou, Zhejiang, China


| Zhou Hongchang
School of Medicine, Huzhou University & Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Prov-ince, Huzhou, Zhejiang, China


| Shang Ya Qian
School of Medicine, Huzhou University & Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Prov-ince, Huzhou, Zhejiang, Chinaa


| Zhang De Long
School of Medicine, Huzhou University & Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Prov-ince, Huzhou, Zhejiang, China


| Chen Gao Qiang
School of Medicine, Huzhou University & Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Prov-ince, Huzhou, Zhejiang, China


| Jiang Bei
School of Medicine, Huzhou University & Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Prov-ince, Huzhou, Zhejiang, China


| Wu Wan Ting
School of Medicine, Huzhou University & Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Prov-ince, Huzhou, Zhejiang, China


| Lu Mingke
School of Life Sciences, Xiamen University, Fujian, China
نشانی اینترنتی https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3872
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