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Iranian Journal of Parasitology، جلد ۱۸، شماره ۴، صفحات ۴۱۹-۴۲۶
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عنوان انگلیسی Field Efficacy of Topical Nano-Liposomal Amphotericin B (Sina Ampholeish®) Alone or in Combination with Glucantime® and Cryotherapy on Human Cutaneous Leishmaniasis
چکیده انگلیسی مقاله Background: Cutaneous leishmaniasis (CL) is a parasitic disease that presents a broad spectrum of clinical features. Treatment of CL is problematic. We aimed to compare the field therapeutic efficacy of topical nanoliposomes containing 0.4% amphotericin B (Nano Lip-AmB) alone and in combination with cryotherapy and/or Glucantime® on human CL in the endemic areas of Iran. Methods: This retrospective study was performed based on the results of using Nano Lip-AmB alone or with Glucantime® and/or cryotherapy in the treatment of zoonotic cutaneous leishmaniasis (ZCL) in patients referred to health centers of Isfahan, Golestan and Ilam Provinces of Iran as endemic foci of ZCL caused by Leishmania major besides Mashhad and Bam cities as endemic foci of anthroponotic cutaneous leishmaniasis (ACL) caused by with L. tropica. Results: Two hundred and seventy-eight patients with CL were included in the current study. All of the patients (100%) who received Nano Lip-AmB alone or in combination with Glucantime® and/or cryotherapy based on guideline of Iranian national committee for the treatment of CL. Two patients with 7 skin lesions, who was resident in ACL endemic area and received Nano Lip-AmB plus Glucantime® and another patient was a resident of ZCL endemic area and received Nano Lip-AmB plus cryotherapy showed clinical relapses after treatment. Conclusion: Sina Ampholeish® in combination with other standard protocols of treatment of CL is well tolerated and with acceptable clinical efficacy rate.
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نویسندگان مقاله | Zahra Alizadeh
Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Mohammad Reza Shirzadi
Zoonoses Control Department, Center for Communicable Diseases Management, Ministry of Health and Medical Ed-ucation, Tehran, Iran


| Gholam Reza Hassanpour
Center for Research of Endemic Parasites of Iran, Tehran University of Medical Sciences, Tehran, Iran


| Hossein Keshavarz
1. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 2. Center for Research of Endemic Parasites of Iran, Tehran University of Medical Sciences, Tehran, Iran


| Fatemeh Mohebali
Materials and Energy Research Center (MERC), Karaj, Iran


| Seyed Ebrahim Skandari
Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran


| Mohammad Zeinali
Zoonoses Control Department, Center for Communicable Diseases Management, Ministry of Health and Medical Ed-ucation, Tehran, Iran


| Sedigheh Shirmohammad
Center for Research of Endemic Parasites of Iran, Tehran University of Medical Sciences, Tehran, Iran


| Mehdi Mohebali
1. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 2. Center for Research of Endemic Parasites of Iran, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3900
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