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Medical Journal of Islamic Republic of Iran، جلد ۲۸، شماره ۱، صفحات ۱۰۵۵-۱۰۶۴
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عنوان انگلیسی Menstrual disturbances and hormonal changes in women workers exposed to a mixture of organic solvents in a pharmaceutical company
چکیده انگلیسی مقاله Background: Chemicals are among risk factors that can affect women's reproductive system. This study is aimed to investigate the association of occupational exposure to a mixture of organic solvents with menstruation disturbances and hormonal changes among female workers. Methods : Female workers of a pharmaceutical company were divided into three groups of non-exposed, low-exposed and highly-exposed to a mixture of organic solvents (formaldehyde, phenol, N-hexane, and chloroform) based on workplace measurements. Menstrual disturbances (in terms of short cycles, long cycles, irregular cycles, and bleeding or spotting between periods) and mean of hormone levels (including follicle stimulating hormone, luteinizing hormone, thyroid stimulating hormone, prolactin, estrogen and progesterone levels) were compared between these three groups. For investigating associations, logistic regression was performed. Results : Our study showed that mean length of cycles, duration of bleeding, and amount of flow and also prevalence of long cycles, irregular cycles, and bleeding or spotting between periods were higher in exposed groups (p≤0.05). Odds ratio for prevalence of menstrual disturbances in the low exposure group and high exposure group were 9.69 (p=0.001) and 3.40 (p=0.002) respectively compared to the reference group. Estrogen and progesterone levels were not affected (p> 0.05), but other hormones levels were significantly disturbed in the exposed groups compared with the non-exposed group (p=0.001). Conclusion : Occupational exposure to the mixture of organic solvents may be associated with the increase of menstrual disorders and hormonal changes in female workers. Based on our findings, periodic evaluation of reproductive system of female workers in pharmaceutical companies is recommended.
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نویسندگان مقاله سمیه حسنی | somayeh hassani
telemedicine research center, national research institute of tuberculosis lung diseases nritld , shahidbeheshti university of medical sciences, tehran, iran.

سازمان های دیگر: مرکز ملی تحقیقات بیماریهای نای

محمد نامور | mohamad namvar
occupational medicine department, school of medicine, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

مریم ghoreishvandi | maryam ghoreishvandi
islamic azad university pharmacology of sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

میرسعید عطارچی | mirsaeed attarchi
occupational medicine department, faculty of medicine, iran university of medical sciences, tehran, iran; brain and spinal cord injury research center basir , tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مجید گل آبادی | majid golabadi
occupational medicine department, school of medicine, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

سید محمد سیدمهدی | seyed mohammad seyedmehdi
chronic respiratory diseases research center, national research institute of tuberculosis lung diseases nritld , shahidbeheshti university of medical sciences, tehran, iran.

سازمان های دیگر: مرکز تحقیقات بیماریهای نای

مهشاد خدارحمیان | mahshad khodarahmian
occupational medicine department, school of medicine, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-766&slc_lang=en&sid=en
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