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Analytical and Bioanalytical Electrochemistry، جلد ۱۵، شماره ۳، صفحات ۲۴۰-۲۵۰
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عنوان انگلیسی Development of Potentiometric Evaluations of Ranitidine in Pure and Pharmaceutical Products
چکیده انگلیسی مقاله Ranitidine ion-selective membrane electrodes were fabricated from PVC matrix and ranitidine hydrochloride (RNH-HCl)-phosphotungestic acid (PTA) as the detecting components in the existence of di-n-octyl phthalate (DOPH), di-n-butyl phthalate (DBPH) and dibutyl phosphate (DBP) as the solvent mediator and plasticizing the PVC membrane. The electrodes were prepared with DOPH (electrode 1), and DBPH (electrode 2) gave a Nernstian, stable, and rapid response, which displayed linear response in the concentration range of 1.0×10-6-1.0×10-2 mol.L-1 and 2.03×10-6-1.0×10-2 mol.L-1, with Nernstian slope of 58.73, and 52.50 mV.decade-1 for electrode 1 and electrode 2 respectively. Limits of detection 9.30×10-7 and 3.70×10-7 mol.L-1 for electrodes 1 and 2, respectively were also obtained. Individual electrodes were operative at the pH range of 3.0-5.5 and 3.5-5.5. The membrane electrodes showed excellent selectivity for the drug ranitidine in comparison with various inorganic cations. The electrodes showed a cycle of 55,50 days not including major variations in the parameters of the electrodes. Sensor 3 was given a non-Nernstian response equal to 28.76 mV.decade-1 and the range of concentration was   2.0×10-6-1.0×10-2 mol.L-1 with a limit of detection near 3.68×10-7 mol.L-1. Ranitidine can be determined effectively in unmixed and pharmaceutical formulations using these designated methods.
کلیدواژه‌های انگلیسی مقاله Ranitidine,Detection limit,plasticizer,Potentiometric method,pharmaceutical products
نویسندگان مقاله Omar Salih Hassan |
Department of Chemistry, College of Education for Pure Science, Tikrit University, Tikrit, Iraq

Salma Anwer Abdullah |
Department of Clinical laboratory sciences, College of Pharmacy, Tikrit University, Tikrit, Iraq

Amina Mohsen Abass |
Department of Chemistry, College of Science, Al-Nahrain University, Al-Jaderia, Baghdad, Iraq

نشانی اینترنتی https://www.abechem.com/article_703904_55971e4c13eb80ec4290541a6dd06f5b.pdf
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