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Veterinary Research Forum، جلد ۱۳، شماره ۳، صفحات ۳۳۹-۳۴۷
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عنوان انگلیسی An ethyl acetate fraction of flavonoids from Polygonum hydropiper L. exhibits an anti-inflammatory activity in PCV2-infected porcine alveolar macrophages via PI3K/Akt and NF-κB pathways
چکیده انگلیسی مقاله Porcine circovirus type 2 (PCV2) widely exists in swine production systems causing porcine circovirus diseases (PCVD) which is associated with significant economic losses. Polygonum hydropiper L. was used as a traditional Chinese medicine to treat a variety of diseases. This study was carried out to investigate anti-inflammatory activity of the ethyl acetate fraction of flavonoids from Polygonum hydropiper L. (FEA) in PCV2-induced porcine alveolar macrophages (3D4/2 cell line). The production of oxygen species (ROS) and the levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-8 (IL-8) were detected to evaluate the anti-inflammatory activities of FEA. The translocation of nuclear factor-kappa B (NF-κB) and the phosphatidylinositol 3 kinase/protein kinase B (PI3K/Akt) signaling pathways were investigated to document the potential anti-inflammatory mechanisms. In PCV2 induced 3D4/2 cells, FEA treatment significantly reduced the production of ROS, and sharply down-regulated the levels of TNF-α, IL-1β and IL-8 in both secretion and mRNA expression level. The FEA also decreased the mRNA expression of Akt and NF-κB p65, reduced the transfer of p65 to nuclear, and inhibited the activation of PI3K/Akt signaling pathway. The findings suggest that FEA exhibited an anti-inflammatory activity in vitro and could be used as a candidate in treatment of inflammation induced by PCV2 infection.
کلیدواژه‌های انگلیسی مقاله 3D4/2 cell,Anti-inflammatory activity,Polygonum hydropiper L,Porcine circovirus type 2
نویسندگان مقاله Chun-Zhi Ren |
Department of Veterinary Pharmacology, College of Animal Science and Technology, Guangxi University, Nanning, China

Wen-Yue Hu |
Department of Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China

Man-ling Song |
Department of Veterinary Pharmacology, College of Animal Science and Technology, Guangxi University, Nanning, China

Ying-Yi Wei |
Department of Veterinary Pharmacology, College of Animal Science and Technology, Guangxi University, Nanning, China

Ting-Jun Hu |
Department of Veterinary Pharmacology, College of Animal Science and Technology, Guangxi University, Nanning, China

نشانی اینترنتی https://vrf.iranjournals.ir/article_252994_f5158994f5c3f7ec2f2a97a32248439e.pdf
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