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Acta Medica Iranica، جلد ۵۴، شماره ۴، صفحات ۲۴۰-۲۴۴
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عنوان انگلیسی Attenuated Lead Induced Apoptosis in Rat Hepatocytes in the Presence of Lycopersicon Esculentum
چکیده انگلیسی مقاله Lead (Pb), has, for decades, being known for its adverse effects on various body organs and systems. In the present study, the damage of Pb on the Liver tissue apoptosis was investigated, and Lycopersicon esculentum as an antioxidants source was administered orally to prevent the adverse effects of Pb. Eighteen Wistar rats, randomized into three groups (n=6), were used for this study. Animals in Group A served as the control and were drinking distilled water. Animals in Groups B and C were drinking 1%Lead acetate (LA). Group C animals were, in addition to drinking LA, treated with 1.5 ml/day of Lycopersicon esculentum. Treatments were for three months. The obtained results showed that lead acetate caused significant reductions in the liver weight, plasma and tissue superoxide dismutase and catalase activity, but a significant increase in plasma and tissue malondialdehyde concentration but Lycopersicon esculentum have an inhibitory effect on LA liver adverse effect. So, it can be concluded that Lycopersicon esculentum have a significant protective effect on liver lead acetate adverse effects as well as, lead acetate -induced oxidative stress.
کلیدواژه‌های انگلیسی مقاله Lead,Apoptosis,Hepatocytes,Lycopersicon
نویسندگان مقاله حمیدرضا احمدی آشتیانی | hamidreza ahmadi ashtiani
cosmetic products research center, iran food and drug adminstration, ministry of health and medical education, tehran, iran. and department of basic sciences, school of veterinary medicine, university of tehran, iran. and pharmaceutical sciences branch, islamic azad university, tehran, iran.

سازمان اصلی تایید شده: وزارت بهداشت درمان و آموزش پزشکی (Ministry of health and medical education)

آرش خاکی | arash khaki
department of pathology, faculty of veterinary, islamic azad university, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

شهرام اجتماعی مهر | shahram ejtemaei mehr
department of pharmacology, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

صغری انجرانی | soghra anjarani
health reference laboratories, ministry of health and medical education, tehran, iran.

سازمان اصلی تایید شده: وزارت بهداشت درمان و آموزش پزشکی (Ministry of health and medical education)

منوچهر دادگرنژاد | manochehr dadgarnejad
cosmetic products research center, iran food and drug adminstration, ministry of health and medical education, tehran, iran.

سازمان اصلی تایید شده: وزارت بهداشت درمان و آموزش پزشکی (Ministry of health and medical education)

محمود آل بویه | mahmoud alebouyeh
cosmetic products research center, iran food and drug adminstration, ministry of health and medical education, tehran, iran.

سازمان اصلی تایید شده: وزارت بهداشت درمان و آموزش پزشکی (Ministry of health and medical education)

حسین رستگار | hossein rastegar
cosmetic products research center, iran food and drug adminstration, ministry of health and medical education, tehran, iran. and pharmaceutical sciences branch, islamic azad university, tehran, iran.

سازمان اصلی تایید شده: وزارت بهداشت درمان و آموزش پزشکی (Ministry of health and medical education)

نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/5584
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