Splenic abscess is a rare disease with growing incidence due to the increasing number of immunocompro-mised patients and usage of improved diagnostic imaging modalities. Hematogenous infections are the most common cause of splenic abscess. Because of nonspecific clinical presentation, diagnosis might be de-layed. CT-scan is the imaging method of choice for diagnosis. Ttreatment includes antibiotics alone or antibiotic therapy with percutaneous drainage or splenectomy. In this article, we present a rare case of multiple splenic abscess (MSA) in a patient undergoing hemodialysis in Bushehr.