این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Nuclear Medicine، جلد ۳۲، شماره ۱، صفحات ۹-۱۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Comparing the diagnostic efficacy of [99mTc]Tc-HYNIC-PSMA-11 SPECT/CT scanning after 75 minutes and 4 hours of radiotracer injection in men with prostate cancer
چکیده انگلیسی مقاله Introduction: Prostate-Specific Membrane Antigen (PSMA) is overexpressed in primary and metastatic prostate carcinoma (PCa) and could be targeted by a [99mTc]Tc-HYNIC-PSMA-11 scan for detection of metastases. Despite extensive studies, data on the most appropriate interval between radiopharmaceutical injection and image acquisition is scarce. We compared the metastasis detection rates of the [99mTc]Tc-HYNIC-PSMA-11 scan between 75-minute and 4-hour intervals of radiopharmaceutical injection.
Methods: From May 2021 to May 2022, we studied 30 consenting men with pathologically confirmed PCa who were referred to our department requesting  a PSMA scan for primary staging, biochemical recurrence, pre-177Lu-PSMA therapy, or surveillance. 75-minute and 4-hour [99mTc]Tc-HYNIC-PSMA-11 SPECT/CT scan performed following injection of the radiopharmaceutical. The corresponding  metastasis detection rates were evaluated in 75-minute and 4-hour intervals.
Results: The mean age of patients was 68.43±9.61 years, with a median PSA of 4.19 ng/ml and a median Gleason Score of 8. Nine cases had negative [99mTc]Tc-HYNIC-PSMA-11 scans, while 21 had positive scans (8 cases with bone, 2 with lung, 4 with lymph node, and 7 with multiple organ metastases). All metastases were detected in both checkpoints, except for one patient, where 75-minute images detected three pelvic metastatic lymph nodes, while four were seen in the 4-hour scan. This small missed right external iliac lymph node did not change the patient’s management.
Conclusion: We found no significant difference in the detection rate of metastatic lesions in 75-minute and 4-hour time intervals. These findings could help to decrease  waiting time and  by more efficient scheduling improves patient’s satisfaction at nuclear medicine departments.
کلیدواژه‌های انگلیسی مقاله [99mTc]Tc-HYNIC-PSMA -11, prostate cancer, Scintigraphy, SPECT/CT, Metastasis
نویسندگان مقاله Azadeh Sahebkari |
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Salman Soltani |
Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Hamidreza Ghorbani |
Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Kamran Aryana |
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Mona Kabiri |
Pharmaceutical Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Kayvan Sadri |
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Mahdi Mottaghi |
Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Atena Aghaee |
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

نشانی اینترنتی http://irjnm.tums.ac.ir/article_40110_7cee7410960800668d858d0745df1a69.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات