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Research in Pharmaceutical Sciences، جلد ۱۹، شماره ۱، صفحات ۱-۱۲
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عنوان انگلیسی The therapeutic value of thiazole and thiazolidine derivatives in Alzheimer's disease: a systematic literature review
چکیده انگلیسی مقاله Background and purpose: Alzheimer's disease (AD) is a common neurodegenerative disease and the fifth leading cause of death among the elderly. The development of drugs for AD treatment is based on inhibiting cholinesterase (ChE) activity and inhibiting amyloid-beta peptide and tau protein aggregations. Many in vitro findings have demonstrated that thiazole- and thiazolidine-based compounds have a good inhibitory effect on ChE and other elements involved in the AD pathogenicity cascade. Experimental approach: In the present review, we collected available documents to verify whether these synthetic compounds can be a step forward in developing new medications for AD. A systematic literature search was performed in major electronic databases in April 2021. Twenty-eight relevant in vitro and in vivo studies were found and used for data extraction. Findings/Results: Findings demonstrated that thiazole- and thiazolidine-based compounds could ameliorate AD's pathologic condition by affecting various targets, including inhibition of ChE activity, amyloid-beta, and tau aggregation in addition to cyclin-dependent kinase 5/p25, beta-secretase-1, cyclooxygenase, and glycogen synthase kinase-3β. Conclusion and implications: Due to multitarget effects at micromolar concentration, this review demonstrated that these synthetic compounds could be considered promising candidates for developing                  anti-Alzheimer drugs.
کلیدواژه‌های انگلیسی مقاله Alzheimer&,#039,s disease,Amyloid beta,Cholinesterase,Glycogen synthase kinase,Thiazolidine,Thiazole
نویسندگان مقاله | Zahra Abdollahi
Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.


| Mojgan Nejabat
Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.


| Khalil Abnous
Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.


| Farzin Hadizadeh


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/2226
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Review Article
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