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Physiology and Pharmacology، جلد ۲۸، شماره ۱، صفحات ۳-۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Impact of saponin on cyclophosphamide -induced testicular damage
چکیده انگلیسی مقاله Introduction: Cyclophosphamide (CP) is the most common chemotherapy drug that has toxic effects on the male reproductive system. This experimental study aimed to assess the protective impact of saponin (SP) on the testicular damage induced via CP.
Methods: Twenty-four male mice were separated randomly into 4 groups (N=6): 1. Control group, 2. CP, 3. SP and 4. CP + SP. CP (15mg/kg/weekly) and SP (2.5 mg/kg/daily) were intraperitoneally injected for 35 consecutive days. At the end of the study, the testicles were removed for the histological and biochemical (MDA, SOD, and GPX) evaluation.
Results: CP induced degenerative changes in testicular tissues and SP treatment reduced these alterations. The results indicated that CP increased MDA levels and reduced SOD, GPX, and testosterone levels (P<0.05) in contrast to the control group. In the CP+SP group, a significant reduction (P<0.01) in MDA levels and the elevation of SOD, GPX, and testosterone levels were observed. 
Conclusion: It seems saponin may reduce CP-induced reproductive toxicity in male mice. 
کلیدواژه‌های انگلیسی مقاله Cyclophosphamide,Oxidative stress,Saponin,Testis
نویسندگان مقاله | Mojgan Timar
Research Laboratory for Embryology and Stem Cells, Department of Anatomical Sciences, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran


| Ramin Salimnejad
Research Laboratory for Embryology and Stem Cells, Department of Anatomical Sciences, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran


| Mohammad Ghasem Golmohammadi
Research Laboratory for Embryology and Stem Cells, Department of Anatomical Sciences, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran


| Shokofeh Banaei
Department of Physiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran


| Zahra Mehraban
Department of Midwifery, Ardabil Branch, Islamic Azad University, Ardabil, IR, Iran
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-15-1874-3&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Toxicology
نوع مقاله منتشر شده Short communication
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