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Physiology and Pharmacology، جلد ۲۸، شماره ۱، صفحات ۴۳-۵۵
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Intranasal administration of human adipose-derived stem cell-conditioned media ameliorates cognitive performance in a rat model of Alzheimer’s disease
چکیده انگلیسی مقاله Introduction: Alzheimer’s disease (AD) is an age-related disorder, characterized by the gradual loss of memory and cognitive function owing to neuronal damage and brain shrinkage. This study aimed to investigate how intranasal injection of human adipose-derived stem cell-conditioned media (hADSC-CM) ameliorates cognitive performance and affects the level of estrogen receptor beta (Erβ) in the hippocampus of rats in an AD model.
Methods: A total of 32 male rats were divided into four groups, including the control, AD model, hADSC-CM, and vehicle groups. The Morris water maze was used to assess the animals’ behavioral changes. Moreover, Nissl and Thioflavin-S staining were performed to evaluate the histology of the hippocampus. Immunohistochemistry was also carried out to evaluate the expression level of Erβ. 
Results: The intranasal injection of hADSC-CM improved the rats’ cognitive performance by reducing the number of dark cells and beta-amyloid plaques in the hippocampus in the AD model. Besides, the intranasal injection of hADSC-CM increased the level of Erβ in this model.
Conclusion: The present findings indicated that the intranasal injection of hADSC-CM ameliorated cognitive function. Amyloid plaques and dark cells also diminished in the CA1 area of the hippocampus. Moreover, the expression level of ERβ increased. It can be concluded that hADSC-CM has significant treatment benefits for AD in rats.
کلیدواژه‌های انگلیسی مقاله Alzheimer’s Disease, Estrogen receptors, Human adipose-drive stem, Cell therapy, Cognitive performance
نویسندگان مقاله | Seyed Amir shaker
Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Houman Parsaei
Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, IranDepartment of Anatomy, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran


| Naser amini
Neuroscience Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Maliheh Nobakht
Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Javad fahanik babaei
Electrophysiology Research Center, Tehran University of Medical Science, Tehran, Iran


| Ali Dadseresht
Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Elham Seidkhani
Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Mina Eftekharzadeh
Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-10-2085-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cell, Stem Cell and Cancer
نوع مقاله منتشر شده Experimental research article
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