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International Journal of Radiation Research، جلد ۲۲، شماره ۲، صفحات ۲۶۵-۲۷۰
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عنوان انگلیسی Maximum PET/CT 18F-FDG uptake of lymph nodes predicts prognosis in esophageal squamous cell carcinoma
چکیده انگلیسی مقاله
Background: In the present study, PET/CT imaging characteristics were explored to investigate the prognostic value of 18F–fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in oesophageal squamous cell carcinoma (ESCC). Materials and Methods: Baseline PET/CT and clinical characteristics were collected in 125 patients with ESCC treated with radical radiotherapy from 2007–2016. The maximum standardized uptake value (SUVmax) of the primary gross tumour (SUVmax-T) and metastatic lymph nodes (SUVmax-N) were separately measured using X-tile. Overall survival (OS) and progression free survival (PFS) were estimated according to the Kaplan–Meier method. A multivariate Cox model was used to establish the independent prognostic factors. Results: The gross tumours presented higher 18F-FDG uptake than normal tissues. The OS and PFS did not show significant differences between patients with different SUVmax-T values. However, patients with SUVmax-N ≥ 11 had a significantly worse OS and PFS than those with SUVmax-N <11 (P<0.05). A weak correlation was observed in SUVmax-T and SUVmax-N. The OS and PFS of patients with PET-negative lymph nodes (LNs) were significantly better than those with PET-positive LNs. However, the OS and PFS of patients with one or two PET-positive LNs were not significantly better than those with more than two PET-positive LNs. In multivariate analysis, SUVmax-N was suggested to be an independent predictor for OS and PFS. Conclusions: SUVmax-N, but not SUVmax-T, is an independent prognostic indicator for patients with ESCC.
کلیدواژه‌های انگلیسی مقاله SUV, positron emission tomography, metabolic lymph node, survival.
نویسندگان مقاله | J. Deng
Department of Radiation Oncology, Fudan University Shanghai Cancer Center; Shanghai, 200032, China


| W. Ren
Department of Radiation Oncology, Fudan University Shanghai Cancer Center; Shanghai, 200032, China


| J. Shen
Department of Radiation Oncology, Fudan University Shanghai Cancer Center; Shanghai, 200032, China


| K. Zhao
Department of Radiation Oncology, Fudan University Shanghai Cancer Center; Shanghai, 200032, China


| K. Zhao
Department of Radiation Oncology, Fudan University Shanghai Cancer Center; Shanghai, 200032, China
نشانی اینترنتی http://ijrr.com/browse.php?a_code=A-10-1-1168&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
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