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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۸، شماره ۲، صفحات ۱۸۳-۱۹۱
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عنوان انگلیسی Hemoglobin C Disorder in Anemic Patients Referred to the National Center for Thalassemia and Genetic Counseling in Damascus
چکیده انگلیسی مقاله Background: Hemoglobinopathies are common inherited blood disorders in our Mediterranean area. The main structural hemoglobin variants are hemoglobin S and hemoglobin C, due to their prevalence. We conducted this retrospective study to investigate and characterize hemoglobin C patients referred to the National Center for Thalassemia and Genetic Counseling and the management of hemoglobin C disease in Damascus. Materials and Methods: The study included patients referred to the National Center for Thalassemia and Genetic Counseling in Damascus between 2000 and 2022 for hemoglobin C detection. Gender, age, geographical origin, hemoglobin electrophoresis profile, and blood transfusion were considered for hemoglobin C patient classification. Blood transfusion in five consecutive years and linear regression with hemoglobin S and C values were determined. Results: 30 (14 males and 16 females) out of 624 patients between 3 and 46 years old (mean ± SD: 17.3 ± 9.7 years) showed hemoglobin C disease. Only eight patients (one male and seven females) received blood transfusions, and the remaining patients (13 males and 9 females) did not receive any transfusion. Only one patient with 100% hemoglobin C was detected; 19 showed HbSC, and 10 had HbAC. There was a significant correlation between hemoglobin S and geographical origin (P-value=0). Conclusion: A Homozygote hemoglobin C patient has mild hemolytic anemia, whereas the hemoglobin C 100% patient has only a one-time blood transfusion (he was 17 years old) in our study. The inherited combination of hemoglobin C and S is less severe than hemoglobin S alone. There is a significant relationship between hemoglobin S and geographical origin (p-value=0).
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نویسندگان مقاله | Aya Ahmad
Department of Pharmacy, Al-Sham Private University, AL-Tall Damascus, Syria


| Karram Fattoum
Department of Pharmacy, Al-Sham Private University, AL-Tall Damascus, Syria


| Wael Imam
Department of Pharmacy, Al-Sham Private University, AL-Tall Damascus, Syria


| MHD Yasser Mukhalalaty
National Center for Thalassemia and Genetic Counseling, Damascus, Syria


| Musab Murad
Department of Pharmacy, Al-Sham Private University, AL-Tall Damascus, Syria


| Faizeh Al Quobaili
Department of Pharmacy, Al-Sham Private University, AL-Tall Damascus, Syria
نشانی اینترنتی https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1847
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