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Iranian Journal of Kidney Diseases، جلد ۱۸، شماره ۲، صفحات ۱۰۸-۱۱۷
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عنوان انگلیسی Risk Factors Analysis of AKI in Patients with Primary Non-small Cell Lung Cancer Treated with PD-1/PD-L1 Inhibitor
چکیده انگلیسی مقاله Introduction. To investigate the risk factors of Programmed CellDeath Protein 1 (PD-1), Programmed Cell Death Ligand 1(PD-L1)inhibitor associated acute kidney injury (AKI) in patients withprimary non-small cell lung cancer (NSCLC) and construct apredictive model.Methods. 120 NSCLC patients were selected as the research subjectsand their clinical data were collected. Patients were divided intoAKI and Non-AKI (N-AKI) group based on the development of AKI.Exploring the risk factors of PD-1P/D-L1 inhibitor related AKI inNSCLC patients using multivariate logistic regression analysis andvisualized the logistic regression analysis to obtain a nomogrammodel. Meanwhile, evaluate the predictive value of the model.Results. The results of multivariate analysis showed that the presenceof extrarenal immune related adverse reactions (irAEs) is a riskfactor for PD-1/PD-L1 inhibitor related AKI in NSCLC patients;At the same time, the risk of developing PD-1/PD-L1 inhibitorrelated AKI in NSCLC patients increases with increasing serumcreatinine (SCr) and C-reactive protein (CRP) levels, decreasingbaseline estimated glomerular filtration rate (eGFR) levels (P < .05).The analysis results of receiver operator characteristic curve (ROC),calibration curve, and decision curve show that the model hasgood discrimination and accuracy, and can achieve a high clinicalbenefit rate.Conclusion. Primary NSCLC patients with extrarenal irAEs, highlevels of SCr and CRP, and low levels of eGFR have a higherrisk of AKI after PD-1/PD-L1 inhibitor treatment. Establishing apredictive model with high accuracy is more conducive to earlydetection of high-risk patients. DOI: 10.52547/ijkd.7964
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نویسندگان مقاله | Jiong-Ming Ying
Department of Medical Oncology, The First People’s Hospital of Hangzhou Lin’an District, Hangzhou 311300, China


| Feng Yan
Department of Medical Oncology, The First People’s Hospital of Hangzhou Lin’an District, Hangzhou 311300, China
نشانی اینترنتی https://ijkd.org/index.php/ijkd/article/view/7964
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کد مقاله (doi) 10.5254/0n3xpz60
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده ORIGINAL | Kidney Diseases
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