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Iranian Journal of Parasitology، جلد ۱۱، شماره ۴، صفحات ۵۳۴-۵۴۱
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عنوان انگلیسی Expression of Pro-inflammatory Genes in Lesions and Neutrophils during Leishmania major Infection in BALB/c Mice
چکیده انگلیسی مقاله Background: Leishmaniasis is a worldwide disease prevalent in tropical and sub- tropical countries in the world. Characterization of inflammatory responses produced in cutaneous leishmaniasis has not yet been completed. Methods: The specific primers were designed for ten pro-inflammatory genes including CCL4, CCL3, TNF-α, IL-1α, IL-12P35, IL-12P40, CCL5, CCR5, IL-1β and IFN- γ and their expression were assessed and compared using RT-PCR in the lesion and peripheral blood neutrophils in Leishmania infected BALB/c mice. Results: None of the pro-inflammatory genes was expressed in the healthy tissue and except IFN-γ others were down-regulated by the parasite in the lesion in untreated mice. In mice treated with anti-Leishmanial drugs, the expression of the pro - inflammatory genes restarted. The figure of pro-inflammatory gene expression in neutrophils was different was from the lesions in treated and untreated mice. Conclusion: Leishmania is capable to suppress the expression of pro-inflammatory genes in the lesions but not in neutrophils. The expression of TNF-α in the lesions and down-regulation of IL-1β in neutrophils could be accounted as an indication for healing of cutaneous leishmaniasis . The results open a new window on characterization of Leishmania lesions and clarifying the role of neutrophils in Leishmania infections.
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نویسندگان مقاله سهیلا اخضری | soheyla akhzari
dept. of laboratory sciences, school of veterinary sciences, bu-ali sina university, hamadan, iran

سازمان اصلی تایید شده: دانشگاه بوعلی سینا (Bu ali sina university)

حسین رضوان | hossein rezvan
dept. of laboratory sciences, school of veterinary sciences, bu-ali sina university, hamadan, iran

سازمان اصلی تایید شده: دانشگاه بوعلی سینا (Bu ali sina university)

مسعود ذوالحواریه | masoud zolhavarieh
dept. of laboratory sciences, school of veterinary sciences, bu-ali sina university, hamadan, iran dept. of clinical sciences, faculty of para-veterinary sciences, bu-ali sina university, hamedan, iran

سازمان اصلی تایید شده: دانشگاه بوعلی سینا (Bu ali sina university)

نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/1353
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/69/article-69-313555.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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