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Journal of Pediatrics Review، جلد ۱۲، شماره ۲، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Diabetes-Associated Autoantibodies and their Relationship to Clinical Characteristics in Children Diagnosed with Type 1 Diabetes
چکیده انگلیسی مقاله
Objectives: This study aimed to determine the frequency of the type 1 diabetes (T1DM) specific auto-antibodies: Glutamic Acid Decarboxylase (GADA), Islet Cell Cytoplasmic (ICA), Insulinoma-Associated-2/Tyrosine Phosphatase (IA-2A), and Insulin autoantibody (IAA).
Methods: This prospective cross-sectional study was conducted from March 2019 to December 2020. Registered type 1 diabetic patients under 18 who visited the diabetes clinic of Bu Ali Sina Hospital of Sari, Iran, were included. The autoantibody, clinical, and biochemistries profile of each participant was recorded.
Results: A total of 190 children diagnosed with type 1 diabetes were included in the study. The mean age of the patients was 13.14 ± 0.36 years. Based on the mono test, the highest prevalence was seen in ICA (104, 66.67 %). Also, based on multiple tests, ICA + GADA had the highest prevalence (135, 49.63%). Patients with positive IA-A2 and ICA compared to negative IA-A2 and ICA had higher age at diabetes onset (8.93 ± 4.11 vs. 7.73 ± 4.33, p= 0.02) (8.8 ± 4.22 vs. 6.81 ± 4.1, p= 0.01) receptively. The HbA1c level at T1DM onset in patients with positive IAA was lower than negative IAA (7.84 ± 1.82 vs. 9.41 ± 2.35, p= 0.0009). There was a significant difference in hyperglycemia with positive and negative IA-A2, in which the chance of positive IA-A2 was 54% lower in hyperglycemia than in euglycemia (OR= 0.46 (0.22-0.96 95% CI), p= 0.04).
Conclusion: the ICA and ICA+GADA had the most prevalence in T1DM patients in northern Iran.
کلیدواژه‌های انگلیسی مقاله Type 1 diabetes, Children and adolescents, Islet autoantibodies ​​​​​​​
نویسندگان مقاله | Niloofaralsadat Motamedi
Department of Pediatrics, Mazandaran University of Medical Sciences, Sari, Iran.


| Daniel Zamanfar
Diabetes Research Center of Mazandaran, Iran


| Fatemeh Rostamian Motlagh
Faculty of Medicine, Azad University of Mazandaran, Sari, Iran.


| Jamshid Yazdani Charati
Department of Biostatistics, Health Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran
نشانی اینترنتی http://jpr.mazums.ac.ir/browse.php?a_code=A-10-1145-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Endocrinology
نوع مقاله منتشر شده Original Article
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