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Iranian Journal of Microbiology، جلد ۱۶، شماره ۳، صفحات ۳۵۱-۳۵۶
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عنوان انگلیسی Immunogenicity of mannan derived from Mycobacterium bovis as a promising adjuvant in vaccine BCG
چکیده انگلیسی مقاله Background and Objectives: Lipoarabinomannan is one of the components of the significant structural cell surfaces of mycobacteria and serves as an immunostimulatory factor. TNF-α and IL-12 are two examples of the anti-bacterial inflammatory cytokines that are activated and induced during infection. Materials and Methods: In this study, mannan was extracted and processed, and then Bulb/c female mice were used in three groups, one group was given BCG vaccine, the other group was given BCG vaccine with mannan adjuvant, and a non-injected group was used as a control group. Inflammatory factors interleukin-12, TNF-α, IgG and IgM were measured in mouse serum. Results: The levels of the inflammatory factors interleukin-12 and TNF-α in the serum isolated from mice receiving the BCG vaccine with mannan adjuvant showed a significant difference compared to the group that received only the BCG vaccine and the control group [IL-12] and , with P≤0.05.The examination of the level of IgG immune factors in these three groups revealed a significant difference. The group that received the BCG vaccine with mannan adjuvant showed a marked contrast compared to the group that received only the BCG vaccine and the control group, with P≤0.05. The level of IgM was higher in the group that received the BCG vaccine alone compared to the adjuvant vaccine group and the control group, with P≤0.05. Conclusion: Our results indicated that mice receiving the BCG vaccine with mannan adjuvant had significantly higher serum levels of IL-12, TNF-α, and IgG than the group receiving BCG alone.
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نویسندگان مقاله | Rajab Mardani
Department of Viral Vaccines, Research and Production Complex, Pasteur Institute of Iran, Tehran, Iran


| Ariana Alavi
Department of Production, Bsc in Biotechnology Pharmaceutical and Drug Delivery System Labratoary, Pasteur Institute of Iran, Tehren, Iran


| Seyed Dawood Mousavi Nasab
Department of Arboviruses and Viral Hemorrhagic Fevers (National Ref Lab), Pasteur Institute of Iran, Tehran, Iran


| Nayebali Ahmadi
Proteomics Research Center, Department of Medical Lab Technology, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Mohammad Javad Hossein Tehrani
Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran


| Maryam Shahali
Department of Viral Vaccines, Research and Production Complex, Pasteur Institute of Iran, Tehran, Iran


| Delaram Doroud
Department of Production, Research and Production Complex, Pasteur Institute of Iran, Tehran, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/4620
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