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Iranian Journal of Nuclear Medicine، جلد ۳۲، شماره ۲، صفحات ۱۵۰-۱۵۶
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عنوان انگلیسی The Role of 1H-MRS and [18F]FDG PET/CT in differentiating primary squamous cell carcinoma and metastatic Hodgkin's lymphoma in lung: An experimental pilot study
چکیده انگلیسی مقاله Introduction: Distinguishing the cellular origin of lung cancer is essential for tailored patient care. This pioneering pilot study explores the synergy of 1H-Magnetic Resonance Spectroscopy (1H-MRS) and 2-[18F] fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography ([18F]FDG PET/CT) in the differentiation of primary squamous cell carcinoma (SCC) of the lung from Hodgkin's lymphoma (HL) metastases.
Methods: Ethically approved, the study enrolled 21 participants with confirmed lung lesions (10 SCC, 11 HL). [18F]FDG PET/CT and 1H-MRS were conducted, and analyses were performed to assess diagnostic potential.
Results: Significant differences in [18F]FDG PET/CT parameters (SUV max BSA, SUV max LBM, and ID%) between SCC and HL were observed. Metabolite concentrations (Cho, Lac, Cr) from 1H-MRS also exhibited distinctions. Correlations between PET values and metabolite concentrations hinted at links between glucose metabolism and molecular composition. Conclusion: This study presents an innovative approach, integrating 1H-MRS and [18F]FDG PET/CT to distinguish primary from metastatic lung lesions. The results hold promise for improving non-invasive diagnostic accuracy and guiding targeted therapies. Future research should validate these findings and explore the potential for clinical integration.
کلیدواژه‌های انگلیسی مقاله Lung cancer differentiation, 1H-MRS, [18F]FDG PET/CT, Squamous cell carcinoma, Hodgkin&apos,s lymphoma
نویسندگان مقاله Marzieh Ebrahimi |
Medical Physics Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Ahmad Bitarafan-Rajabi |
Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

Zeinab Paymani |
Nuclear Medicine Department, Children Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran

Armaghan Fard-Esfahani |
Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Siavash Kooranifar |
Hazrat-e Rasool Hospital, Iran University of Medical Sciences, Tehran, Iran

Arash Zare-Sadeghi |
Medical Physics Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Samira Raminfard |
Advanced Diagnostic and Interventional Radiology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Mostafa Nazari |
Nuclear Medicine Department, Children Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran

نشانی اینترنتی http://irjnm.tums.ac.ir/article_40146_265e17462c838992f326573525612b96.pdf
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