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Iranian Journal of Nuclear Medicine، جلد ۳۲، شماره ۲، صفحات ۱۶۵-۱۷۴
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عنوان انگلیسی Negligible influence of proton pump inhibitors on gastric wall uptake of [99mTc]Tc-MIBI in myocardial perfusion imaging
چکیده انگلیسی مقاله Introduction: Myocardial perfusion imaging (MPI) faces a challenge in diagnostic accuracy due to gastric wall uptake (GWU). Previous studies have linked GWU to proton pump inhibitors (PPIs) intake, but only a minority of patients on PPIs show activity accumulation. Our study aimed to investigate the influence of PPIs on GWU in MPI by single photon emission computed tomography (SPECT) and assess the necessity or benefits of discontinuing PPIs before the procedure.
Methods: The 368 patients who underwent a two-day stress/rest [99mTc]Tc-MIBI SPECT/CT MPI were divided into three groups: (i) Control group (n=114, without the consumption of any gastroprotective medication), (ii) continued medication(n=48, on PPI treatment) and (iii) discontinued medication (n=206, PPI discontinued for one day or more before MPI). Rest SPECT images were analysed for clinically relevant GWU.
Results: Based on our study, out of 114 patients in group (i),16 individuals (14%), and 10 patients from 48 patients in group (ii) (20.8%) demonstrated radioactivity accumulation in the gastric wall. In group (iii) despite discontinuing PPIs use, 20.3% of patients showed GWU. Statistical analysis of these three groups and their subgroups did not show any significant difference in terms of gastric wall uptake of [99mTc]Tc-MIBI in MPI.
Conclusion: Concisely, our study found no significant link between PPI use and gastric wall activity in MPI. Further data is needed before adjusting drug guidelines in nuclear medicine centers. Multicenter studies with larger patient cohorts must explore the PPI-GWU relationship, utilizing SPECT/CT scans for precise interference location determination.
کلیدواژه‌های انگلیسی مقاله Proton pump inhibitors, Gastric wall uptake, [99mTc]Tc-MIBI, Myocardial perfusion imaging, SPECT/CT
نویسندگان مقاله Raheleh Hedayati |
Department of Nuclear Medicine, School of Medicine, Hasheminejad Hospital, Iran University of Medical Sciences, Tehran, Iran

Seyedeh Farnaz Siadati |
Department of Nuclear Medicine, School of Medicine, Rajaie Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

Nahid Yaghoobi |
Department of Nuclear Medicine, School of Medicine, Rajaie Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

Hadi Malek |
Department of Nuclear Medicine, School of Medicine, Rajaie Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

Zahra Jamshidi Araghi |
Department of Nuclear Medicine, School of Medicine, Rajaie Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

Mohammad Chehreghani |
Department of Nuclear Medicine, School of Medicine, Rajaie Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

Leila Hassanzadeh |
Department of Nuclear Medicine, School of Medicine, Rajaie Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

نشانی اینترنتی http://irjnm.tums.ac.ir/article_40154_d23fd0900a785be7d33a2fa31d12b24a.pdf
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