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Iranian Journal of Nuclear Medicine، جلد ۳۲، شماره ۲، صفحات ۲۲۹-۲۳۲
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عنوان انگلیسی De novo metastatic prostate cancer with neuroendocrine differentiation: A diagnostic dilemma
چکیده انگلیسی مقاله De novo metastatic prostate cancer with neuroendocrine differentiation (NED) at first presentation is extremely rare. A 65-year-old man (Gleason score 5+4, first assumed to be acinar adenocarcinoma), was referred for [99mTc]Tc-HYNIC-PSMA SPECT/CT due to low back pain. The PSA levels were 8 and <0.07 ng/mL at the time of diagnosis and prior to scintigraphy respectively. The scan revealed multiple non-PSMA-avid lesions throughout the skeleton, lung and liver, suggesting the possibility of NED or 2nd malignancy.  Second-look and review of the pathology led to change of the diagnosis to mixed small cell neuroendocrine carcinoma-acinar adenocarcinoma. This case highlights the importance of PSMA imaging in suggestion of type of the tumor which as in our case, might alter the pathologic tissue diagnosis.
کلیدواژه‌های انگلیسی مقاله prostate cancer, Neuroendocrine differentiation, [99mTc]Tc-PSMA, SPECT/CT
نویسندگان مقاله Somaye Barashki |
Nuclear Medicine Research Center, Mashhad University of Medical Science, Mashhad, Iran

Emran Askari |
Nuclear Medicine Research Center, Mashhad University of Medical Science, Mashhad, Iran

Mahmoudreza Kalantari |
Department of Pathology, Faculty of Medicine, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

Hadis Mohammadzadeh Kosari |
Nuclear Medicine Research Center, Mashhad University of Medical Science, Mashhad, Iran

Kamran Aryana |
Nuclear Medicine Research Center, Mashhad University of Medical Science, Mashhad, Iran

نشانی اینترنتی http://irjnm.tums.ac.ir/article_40148_4a05dc1c7cb5729955565b2a77526e9a.pdf
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