این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Medical Journal of Islamic Republic of Iran، جلد ۲۸، شماره ۱، صفحات ۸۹۲-۸۹۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Association of the CTLA-4 1722TC polymorphism and systemic lupus erythematosus: a systematic review and meta analysis
چکیده انگلیسی مقاله Background :Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is an important negative regulator of T-cell responses. The -1722TC polymorphism of the CTLA-4 gene may be associated with systemic lupus erythematosus (SLE) risk, but related results from previous studies have been inconsistent. We carried out a meta-analysis to assess this association more precisely. Methods : A systematic search through PubMed, Science Direct, and OVID, Iran doc, Iranmedex and SID (Scientific Information Database) databases was performed with the last search updated on December 30, 2011. The odds of ratio (OR) and its 95% confidence interval (95%CI) were used to assess the strength of the association. We evaluated both fixed and random effect models, depending on the presence of between-study heterogeneity. The analyses were conducted using STATA software, version 11.0. Results : A total of 9 independent studies on the CTLA-4 gene -1722TC polymorphism and SLE, including 1422 cases and 1417 controls were used in this meta-analysis. In the present meta-analysis, we found a significant association between -1722TC polymorphism and SLE risk in the overall analysis (TT versus TC/CC: OR=1.18, 95%CI 0.84-1.66, p= 0.32 TT/TC versus CC: OR = 2.06, 95%CI 1.07–3.99, p= 0.03 TT versus CC: OR = 2.32, 95%CI 1.62–3.32, p< 0.001 TC versus CC: OR = 1.99, 95%CI 1.42–2.78, p< 0.001 TT versus TC: OR = 1.2, 95%CI 0.86–1.66, p= 0.28 T versus C: OR = 1.22, 95%CI 0.91–1.64, p= 0.16). In the subgroup analysis by ethnicity, -1722TC polymorphism was significantly associated with SLE risk in Asian population. Conclusion : This meta-analysis suggests a significant association between -1722TC polymorphism and SLE susceptibility. Large-scale and well-designed case-control studies are necessary to validate the risk identified in the present meta-analysis.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله مهدیه شجاع | mahdieh shojaa
rheumatology research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سازمان های دیگر: Rheumatology Research Center

مهرداد آقایی | mehrdad aghaie
department of medicine, golestan university of medical sciences, gorgan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

مصطفی قربانی | mostafa qorbani
department of community medicine, alborz university of medical sciences, karaj, iran amp; non-communicable diseases research center, endocrinology and metabolism population sciences institute, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سازمان های دیگر: Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute |Alborz University of Medical Sciences

پاتریشیا خشایار | patricia khashayar
osteoporosis research center, endocrinology and metabolism clinical sciences institute, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سازمان های دیگر: Endocrinology and Metabolism Clinical Sciences Institute

مهسا آملی | mahsa amoli
endocrinology and metabolism research center, endocrinology and metabolism clinical sciences institute, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سازمان های دیگر: Endocrinology and Metabolism Research Center | Endocrinology and Metabolism Clinical Sciences Institute

عباسعلی کشتکار | abbas ali keshtkar
osteoporosis research center, endocrinology and metabolism clinical sciences institute, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سازمان های دیگر: Osteoporosis Research Center | Endocrinology and Metabolism Clinical Sciences Institute

رامین محبی | ramin mohebi
department of internal medicine, school of medicine, shahed university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

حسین انصاری | hossein ansari
health promotion research center, zahedan university of medical sciences, zahedan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)
سازمان های دیگر: Health Promotion Research Center

حمید آسایش | hamid asayesh
department of medical emergencies, qom university of medical sciences, qom, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی قم (Qom university of medical sciences)

شیما رکن شریفی | shima rokn sharifi
rheumatology research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سازمان های دیگر: Rheumatology Research Center

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1569-14&slc_lang=en&sid=en
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده 3
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات