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Iranian Journal of Nuclear Medicine، جلد ۲۴، شماره ۱، صفحات ۲۹-۳۶
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عنوان انگلیسی Optimized production and quality control of 68Ga-DOTATATE
چکیده انگلیسی مقاله Introduction: Optimized production and quality control of 68Ga-DOTATATE as an efficient and preferable PET radiotracer for somatostatin receptor imaging in neuroendocrine tumors is of great interest. In this study effort has been made to present a fast, efficient, cost-effective and facile protocol for 68Ga-DOTATATE productions for clinical trials. Methods:68Ga-DOTATATEwas prepared using generator-based [68Ga]GaCl3 and DOTATATE at optimized conditions for time, temperature, ligand amount, gallium content and column cartridge purification followed by proper formulation. The biodistribution of the tracer in rats was studied using tissue counting and PET/CT imaging up to 120 min. Results:68Ga-DOTATATE was prepared at optimized conditions in 7-10 min at 95°C followed by SPE using C18 cartridge (radiochemical purity»99±0.88% ITLC, >99% HPLC, specific activity: 1200-1850 MBq/nM). The biodistribution of the tracer demonstrated high kidney uptake of the tracer in 10-20 min consistent with reported somatostatin receptor mappings. Conclusion: The entire production and quality control of 68Ga-DOTATATE is presented including labeling, purification, HPLC analysis, sterilization and LAL test) took 18-20 min with significant specific activity for administration to limited number of patients in a PET center.
کلیدواژه‌های انگلیسی مقاله 68Ga-DOTATATE,Production,Quality control,optimization,PET/CT
نویسندگان مقاله ایوب آقانژاد |
radiation application research school, nuclear science and technology research institute, tehran, iran

امیررضا جلیلیان | amir reza
radiation application research school, nuclear science and technology research institute, tehran, iran

استپان maus |
clinic of nuclear medicine, university medical centre mainz, langenbeckstrasse 1, d-55131 mainz, germany

حسن یوسف نیا |
radiation application research school, nuclear science and technology research institute, tehran, iran

پرهام گرامی فر |
research center for nuclear medicine, shariati hospital, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

داود بیکی |
research center for nuclear medicine, shariati hospital, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://irjnm.tums.ac.ir/article_15756_4fd002269136630b060915fe73762a51.pdf
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