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Iranian Journal of Nuclear Medicine، جلد ۲۴، شماره ۱، صفحات ۴۶-۵۰
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عنوان انگلیسی Optimized preparation and evaluation of 99mTc-Streptomycin
چکیده انگلیسی مقاله Introduction: The endemic occurrence of new strains of tuberculosis around the globe has initiated new research on developing diagnostic radiopharmaceutical based on antibiotics. Methods:Tc-99m labeled streptomycin was prepared using freshly milked 99mTcO4- and various concentrations of streptomycin, stannous chloride at various temperatures in high yield radiochemical purity shown by HPLC/RTLC. Results:At various pHs tested (3-10) the best labeling yield at optimized conditions were at 6-8 range, however pH.7 was considered the best. The radiochemical purity at the best optimized conditions was >95% as shown by RTLC and >97% using HPLC (specific activity; 1-3 GBq/mmole). The tracer proved to be stable in the final product and in presence of human serum at 37°C up to 2h. However, biodistribution and high resolution SPECT studies in wild type mice showed instability of the complex due to high stomach and thyroid activity uptake. Conclusion: Regardless the reported methods in the literature the direct 99mTc-labeling of aminoglycosides did not proved a suitable tracer.
کلیدواژه‌های انگلیسی مقاله Technetium-99m,Streptomycin,SPECT,Biodistribution
نویسندگان مقاله علی بادبرین |
radiation application research school, nuclear science and technology research institute, tehran, iran

امیررضا جلیلیان | amir reza
radiation application research school, nuclear science and technology research institute, tehran, iran

حسن یوسف نیا |
radiation application research school, nuclear science and technology research institute, tehran, iran

محمد مزیدی |
radiation application research school, nuclear science and technology research institute, tehran, iran

فاطمه bolourinovin |
radiation application research school, nuclear science and technology research institute, tehran, iran

نشانی اینترنتی http://irjnm.tums.ac.ir/article_15758_926c4747f0e55a727ba88fa4fa446d3c.pdf
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