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Iranian Journal of Nuclear Medicine، جلد ۲۴، شماره ۱، صفحات ۵۹-۶۴
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عنوان انگلیسی Preclinical studies of 166Ho-chitosan for treatment of hepatocellular carcinoma
چکیده انگلیسی مقاله Introduction: Recently, due to the special characteristics of 166Ho and chitosan, 166Ho-chitosan complex was developed for treatment of tumors such as hepatocellular carcinoma. This complex has been lately prepared with high radiochemical purity in our lab. The preclinical studies of the complex however should be performed to evaluate the tracer concentration in target and normal tissues before human use. Methods:In this study, 166Ho-chitosan was prepared and its preclinical studies for treatment of hepatocellular carcinoma was carried out by injection of the radiopharmaceutical into the rabbit`s liver via two different methods, surgery and venography. Leakage of the injected activity from the injection site in the rabbit organs was investigated using SPECT and SPECT-CT imaging up to 24 hours. Results:Both SPECT and SPECT-CT imaging of the rabbits showed that there was no significant leakage of the injected activity. Almost all the activity would remain in the injection site at least 24 h post injection. Conclusion: Considering all of the excellent features of the complex, this radiopharmaceutical is suggestive for treatment of hepatocellular carcinoma by radioembolization method.
کلیدواژه‌های انگلیسی مقاله Chitosan,Holmium-166,Hepatocellular carcinoma,SPECT,SPECT/CT
نویسندگان مقاله حسن یوسف نیا |
radiation application research school, nuclear science and technology research institute, tehran, iran

احمد بیطرفان رجبی | bitarafan rajabi
cardiovascular intervention research center, rajaie cardiovascular medical and research center, iran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

میرسپهر پدرام | mir sepehr
department of surgery and radiology, faculty of veterinary medicine, university of tehran, tehran, iran
سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

سمانه ذوالقدری |
radiation application research school, nuclear science and technology research institute, tehran, iran

علی بهرامی سامانی | bahrami samani
radiation application research school, nuclear science and technology research institute, tehran, iran

امیررضا جلیلیان | amir reza
radiation application research school, nuclear science and technology research institute, tehran, iran

محمد مزیدی |
radiation application research school, nuclear science and technology research institute, tehran, iran

امیر دربندی آزاد | darbandi azad
rajaie cardiovascular medical and research center, iran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

محمد قنادی مراغه | ghannadi maragheh
radiation application research school, nuclear science and technology research institute, tehran, iran

نشانی اینترنتی http://irjnm.tums.ac.ir/article_15760_79a6a373bfa073b2ea7634b7673d1d54.pdf
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