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Iranian Journal of Nuclear Medicine، جلد ۲۳، شماره ۲، صفحات ۶۵-۷۲
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عنوان انگلیسی Preparation of a 153Sm-5,10,15,20-tetrakis(4-methoxyphenyl) porphyrin complex as a possible therapeutic agent
چکیده انگلیسی مقاله Introduction: Porphyrins are interesting derivatives with low toxicity, tumor avidity and rapid wash-out suggested as potential radiopharmaceuticals in radiolabeled form. In this work we report, synthesis, radiolabeling, quality control, stability, partition coefficient determination and biodistribution studies of 153Sm-5,10,15,20-tetrakis(4-methoxyphenyl) porphyrin (153Sm-4-MPP) in wild-type rats. Methods: [153Sm]-4MPP was prepared using [153Sm]SmCl3 and 5,10,15,20-tetrakis(4-methoxyphenyl) porphyrin (H2-4MPP) for 18 h at 80-90°C. Stability of the complex was checked in final formulation and in presence of human serum for 24 h. The biodistribution of the labeled compound in vital organs of wild-type rats was studied. A detailed comparative pharmacokinetic study performed for 153Sm cation and [153Sm]-4-MPP up to 24h. Results: The radiochemical purity of [153Sm]-4MPP was reported >97±2% and >99±0.5% by ITLC and HPLC, respectively. The specific activity was 220-230 MBq/mmol. The calculated partition coefficient for the compound was (log P=-1.09). The complex is mostly cleared from the circulation through kidneys and liver. The kidney:blood and kidney:muscle ratios 24 h post injection were 14.75 and 42.4, respectively. kidney/liver ratio was almost constant at all time intervals (0.6). Conclusion: [153Sm]-4MPP was prepared at the optimized conditions and suitable characteristics. Further investigations such as biological studies of this agent on tumor-bearing models are needed.
کلیدواژه‌های انگلیسی مقاله Porphyrins,Quality control,Sm-15,Biodistribution
نویسندگان مقاله نسیم وحیدفر |
department of radiopharmacy, faculty of pharmacy, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

امیررضا جلیلیان | amir reza
radiopharmacy research group, radiation application research school, nuclear science and technology research institute, tehran, iran

یوسف فضایلی |
radiopharmacy research group, radiation application research school, nuclear science and technology research institute, tehran, iran

علی بهرامی سامانی | bahrami samani
radiopharmacy research group, radiation application research school, nuclear science and technology research institute, tehran, iran

داود بیکی |
research center for nuclear medicine, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

علی خلج |
department of radiopharmacy, faculty of pharmacy, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://irjnm.tums.ac.ir/article_13270_0ae2e1a24dae9cc6b1f9f93ab987caa5.pdf
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