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Iranian Journal of Basic Medical Sciences، جلد ۲۷، شماره ۱۰، صفحات ۱۲۲۸-۱۲۴۲
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عنوان انگلیسی Medicinal potential of embelin and its nanoformulations: An update on the molecular mechanism and various applications
چکیده انگلیسی مقاله Natural herbs have garnered significant research recently as their components target multiple disease signaling pathways, making them highly potential for various disease prevention and treatment. Embelin, a naturally occurring benzoquinone isolated from Embelia ribes, has shown promising biological activities such as antitumor, antidiabetic, anti-oxidant, and antimicrobial. Various mechanisms have been reported, including monitoring genes that synchronize the cell cycle, up-regulating multiple anti-oxidant enzymes, suppressing genes that prevent cell death, influencing transcription factors, and preventing inflammatory biomarkers. However, the hydrophobic nature of embelin leads to poor absorption and limits its therapeutic potential. This review highlights a wide range of nanocarriers used as delivery systems for embelin, including polymeric nanoparticles, liposomes, nanostructured lipid carriers, micelles, nanoemulsion, and metallic nanoparticles. These embelin nanomedicine formulations have been developed in preclinical studies as a possible treatment for many disorders and characterized using various in vitro, ex vivo, and in vivo models.
کلیدواژه‌های انگلیسی مقاله Embelin, Nanoparticles, Pharmacokinetics, Pharmacologic actions, Structure-activity- relationship
نویسندگان مقاله | Asad Ali
Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, India


| Nasr Emad
Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, India


| Niha Sultana
Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, India


| Hamad Ali
Department of Phytochemistry and Pharmacognosy, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, India


| Samreen Jahan
Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, India


| Mohd Aqil
Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, India


| Mohd Mujeeb
Department of Phytochemistry and Pharmacognosy, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, India


| Yasmin Sultana
Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, India
نشانی اینترنتی https://ijbms.mums.ac.ir/article_24665.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Review Article
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