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Iranian Journal of Nuclear Medicine، جلد ۲۰، شماره ۱، صفحات ۱۹-۲۴
عنوان فارسی
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عنوان انگلیسی Preparation and quality control of scandium-46 bleomycin as a possible therapeutic agent
چکیده انگلیسی مقاله Introduction: Due to interesting therapeutic properties of 46Sc and antineoblastic antibiotic, bleomycin (BLM), 46Sc-bleomycin (46Sc-BLM) was developed as a possible therapeutic compound. Methods: In this work, Sc-46 chloride was obtained by thermal neutron flux (4 × 1013 n.cm-2.s-1) of natural metallic scandium sample followed by dissolution in acidic media as a substitute for 47Sc in radiolabeling studies which was further used for labeling of bleomycin (BLM) followed by stability studies as well as biodistribution in wild-type rats. Results: Sc-46 was obtained in high radiochemical purity (ITLC, >99%, two systems) as well as acceptable specific activity. At optimized conditions a radiochemical purity of 98% was obtained for 46Sc-BLM shown by ITLC (Specific activity, 740 GBq/mmole). The accumulation of the radiolabeled compound in lungs, liver and spleen demonstrates a similar pattern to the other radiolabeled bleomycins. Conclusion: Sc-BLM is a possible therapeutic agent in human malignancies and the efficacy of the compound should be tested in various tumor-bearing models.
کلیدواژه‌های انگلیسی مقاله Bleomycin,Sc-46,Biodistribution,Radiolabeling
نویسندگان مقاله لیلا مقدم بنایم | moghaddam banaem
radiopharmaceutical research and development lab rrdl , nuclear science and technology research institute nstri , atomic energy organization of iran, tehran, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

امیررضا جلیلیان | amir reza
radiopharmaceutical research and development lab rrdl , nuclear science and technology research institute nstri , atomic energy organization of iran, tehran, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

محمدرضا پورجاوید |
radiopharmaceutical research and development lab rrdl , nuclear science and technology research institute nstri , atomic energy organization of iran, tehran, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

علی بهرامی سامانی | bahrami samani
radiopharmaceutical research and development lab rrdl , nuclear science and technology research institute nstri , atomic energy organization of iran, tehran, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

محمد مزیدی |
radiopharmaceutical research and development lab rrdl , nuclear science and technology research institute nstri , atomic energy organization of iran, tehran, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

محمد قنادی مراغه | ghannadi maragheh
radiopharmaceutical research and development lab rrdl , nuclear science and technology research institute nstri , atomic energy organization of iran, tehran, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

نشانی اینترنتی http://irjnm.tums.ac.ir/article_1208_7c52a1fc54c783a510bc10031a17d3c2.pdf
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