این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Nuclear Medicine، جلد ۱۸، شماره ۲، صفحات ۲۹-۳۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Production, quality control and imaging of 64Cu-ATSM in healthy rabbits for clinical applications
چکیده انگلیسی مقاله Introduction: [64Cu]diacetyl-bis(N4-methylthiosemicarbazone) ([64Cu]ATSM) is a well-established hypoxia imaging tracer with reproducible production and significant specifity. In this work the high yield production and quality control as well as imaging studies in healthy rabbits is reported. Methods: Copper-64 produced via the 68Zn(p,an)64Cu nuclear reaction (30 MeV protons at 180 µA) was used for the preparation of [64Cu]diacetyl-bis(N4-methylthiosemicarbazone)([64Cu]ATSM). Followed by quality control and administration to healthy rats as well as healthy rabbits for biodistribution and imaging studies respectively. Results: 64Cu2+ (500 mCi, separation yield> 95%, radionuclide purity>96%) was used for [64Cu]ATSM production (radiochemical purity>99%, specific activity of 300 Ci/mmol) followed by administration to healthy rabbits and coincidence imaging demonstrating uptake in liver, kidney and bowel as shown by other reports in various rodents and human. Conclusion: [64Cu]ATSM radiopharmaceutical is produced and now available in large quantities for research and/or clinical trials in the country.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله یوسف فضایلی |
nuclear medicine research group, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran,karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

امیررضا جلیلیان | amir reza
radiopharmaceutical research and development laboratory, nuclear science and technology research institute, atomic energy organization of iran, tehran, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

محسن کمالی دهقان | kamali dehghan
nuclear medicine research group, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran,karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

فاطمه bolourinovin |
nuclear medicine research group, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran,karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

صدیقه مرادخانی |
nuclear medicine research group, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran,karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

غلامرضا اصلانی |
nuclear medicine research group, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran,karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

علی رحیم نژاد |
nuclear medicine research group, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran,karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

محمد قنادی مراغه | ghannadi maragheh
radiopharmaceutical research and development laboratory, nuclear science and technology research institute, atomic energy organization of iran, tehran, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

نشانی اینترنتی http://irjnm.tums.ac.ir/article_561_49fd0522c3d88914ca5ddd08656606e4.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات