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Iranian Journal of Nuclear Medicine، جلد ۱۸، شماره ۱، صفحات ۱۴-۲۱
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عنوان انگلیسی Preliminary imaging studies of [61Cu]diacetyl-bis (N4-methylthiosemi-carbazone) in normal and hypoxic tumor models
چکیده انگلیسی مقاله Introduction: [61Cu]diacetyl-bis(N4-methylthiosemicarbazone) ([61Cu]ATSM) is a well-established hypoxia imaging tracer with simple production and significant specifity. In this work the accumulation of the tracer is studied in wild-type, necrotic and hypoxic fibrosarcoma tumors. Methods: [61Cu]ATSM was prepared using ATSM ligand and [61Cu]CuOAc followed by i.v. administration and imaging studies in wild-type rats and hypoxic fibrosarcoma-bearing mice. Results: [61Cu]ATSM with high radiochemical purity (>99%, HPLC, RTLC) was injected to wild-type rats as well as hypoxic and necrotic fibrosarcoma-bearing mice followed by imaging up to 3 hours. Conclusion: [61Cu]ATSM was mainly accumulated in liver, as well as kidney and bladder and less but still significant in brain of wild-type rats. A significant and hypoxia-specific tumor/non tumor ratio in hypoxic models was observed by co-incidence imaging 2 h post injection, while in necrotic and 12-week tumor-induced mice very slight tumor uptakes were detected. [61Cu]ATSM is a positron emission tomography (PET) radiotracer for selective tumor hypoxia imaging from necrotic and proliferative tumors.
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نویسندگان مقاله امیررضا جلیلیان | amir reza
radiopharmaceutical research and development laboratory, nuclear science and technology research institute, atomic energy organization of iran, tehran, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

حسن یوسف نیا |
radiopharmaceutical research and development laboratory, nuclear science and technology research institute, atomic energy organization of iran, tehran, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

محسن کمالی دهقان | kamali dehghan
agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

صدیقه مرادخانی |
agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

فاطمه bolourinovin |
agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

کمال الدین شفایی |
agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

غلامرضا اصلانی |
agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

نشانی اینترنتی http://irjnm.tums.ac.ir/article_546_d5c71daab991f2a4a4a784462382eed5.pdf
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